Document Detail


The right ventricular systolic to diastolic duration ratio: a simple prognostic marker in congenital diaphragmatic hernia?
MedLine Citation:
PMID:  21457303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: (i) To compare the ratio of right ventricular systolic to diastolic duration (SD/DD) in infants with congenital diaphragmatic hernia (CDH) and normal controls and (ii) to examine its association, if any, with outcomes in CDH.
METHODS:   Retrospective chart and echocardiographic review of consecutive neonates (<1 month old) with CDH and term controls without structural heart defects. Right ventricular SD/DD was calculated by a single reader.
RESULTS: Infants with CDH (n = 29) were comparable to controls (n = 27) in their mean (SD) age [2.2 (3.3) vs. 2 (4.0) days], birthweight [3 (0.67) vs. 3 (0.69) kg] and proportion of males (48.2% vs. 72.4%). The DD and SD/DD were significantly abnormal in the CDH group, compared to controls. Among infants with CDH, those who died (n = 15) and those who died or required ECMO (n = 17) had significantly shorter DD and higher SD/DD ratio. At a cut-off of 1.3, SD/DD ratio had a sensitivity of 92.8 (95% CI 64-99%) and specificity of 61.5 (32-85%) for prediction of mortality. Significant independent associations with mortality were observed with antenatal diagnosis (p = 0.003) and higher SD/DD ratio (p = 0.04).
CONCLUSION: The right ventricular SD/DD ratio is a sensitive objective prognostic marker in infants with CDH. Further studies incorporating SD/DD ratio as a guide to intervention are warranted.
Authors:
Sanjeev Aggarwal; Paul T Stockman; Michael D Klein; Girija Natarajan
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Publication Detail:
Type:  Journal Article     Date:  2011-05-05
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  100     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-15     Completed Date:  2012-03-29     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1315-8     Citation Subset:  IM    
Copyright Information:
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Diastole / physiology*
Female
Hernia, Diaphragmatic / congenital*,  mortality,  physiopathology,  ultrasonography
Humans
Infant, Newborn
Male
Prognosis
ROC Curve
Reference Values
Retrospective Studies
Sensitivity and Specificity
Survival Analysis
Systole / physiology*
Ventricular Dysfunction, Right* / etiology,  ultrasonography
Ventricular Function, Right*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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