Document Detail

The right ventricular Systolic to Diastolic Duration Ratio: A Simple prognostic marker in Congenital Diaphragmatic Hernia?
MedLine Citation:
PMID:  21457303     Owner:  NLM     Status:  Publisher    
Aims:  a) To compare the ratio of right ventricular systolic to diastolic duration (SD/DD) in infants with congenital diaphragmatic hernia (CDH) and normal controls and b) to examine its association, if any, with outcomes in CDH. Methods:  Retrospective chart and echocardiographic review of consecutive neonates (< 1 month old) with CDH and term controls without structural heart defects. Right ventricular SD/DD was calculated by a single reader. Results:  Infants with CDH (n=29) were comparable to controls (n=27) in their mean (SD) age {2.2 (3.3) vs. 2 (4.0) days}, birth weight {3 (0.67) vs. 3 (0.69) kg} and proportion of males (48.2 vs. 72.4%). The DD and SD/DD were significantly abnormal in the CDH group, compared to controls. Among infants with CDH, those who died (n=15) and those who died or required ECMO (n=17) had significantly shorter DD and higher SD/DD ratio. At a cutoff of 1.3, SD/DD ratio had a sensitivity of 92.8 (95% CI 64-99%) and specificity of 61.5 (32-85%) for prediction of mortality. Significant independent associations with mortality were observed with antenatal diagnosis (p=0.003), and higher SD/DD ratio (p=0.04). Conclusion:  The right ventricular SD/DD ratio is a sensitive objective prognostic marker in infants with CDH. Further studies incorporating SD/DD ratio as a guide to intervention are warranted.
Sanjeev Aggarwal; Paul T Stockman; Michael D Klein; Girija Natarajan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-1
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Department of Pediatrics Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, MI 48201.
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