Document Detail


The right inhibition? Callosal correlates of hand performance in healthy children and adolescents callosal correlates of hand performance.
MedLine Citation:
PMID:  22438280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous studies suggest that interhemispheric inhibition-relayed via the corpus callosum-plays an important role in unilateral hand motions. Interestingly, transcallosal inhibition appears to be indicative of a strong laterality effect, where generally the dominant hemisphere exerts inhibition on the nondominant one. These effects have been largely identified through functional studies in adult populations, but links between motor performance and callosal structure (especially during sensitive periods of neurodevelopment) remain largely unknown. We therefore investigated correlations between Purdue Pegboard performance (a test of motor function) and local callosal thickness in 170 right-handed children and adolescents (mean age: 11.5 ± 3.4 years; range, 6-17 years). Better task performance with the right (dominant) hand was associated with greater callosal thickness in isthmus and posterior midbody. Task performance using both hands yielded smaller and less significant correlations in the same regions, while task performance using the left (nondominant) hand showed no significant correlations with callosal thickness. There were no significant interactions with age and sex. These links between motor performance and callosal structure may constitute the neural correlate of interhemispheric inhibition, which is thought to be necessary for fast and complex unilateral motions and to be biased towards the dominant hand.
Authors:
Florian Kurth; Emeran A Mayer; Arthur W Toga; Paul M Thompson; Eileen Luders
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-22
Journal Detail:
Title:  Human brain mapping     Volume:  34     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-21     Completed Date:  2014-03-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2259-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc., a Wiley company.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Corpus Callosum / anatomy & histology*,  physiology*
Female
Functional Laterality / physiology
Hand / physiology*
Humans
Magnetic Resonance Imaging
Male
Neural Inhibition / physiology*
Psychomotor Performance / physiology*
Grant Support
ID/Acronym/Agency:
AG016570/AG/NIA NIH HHS; EB01651/EB/NIBIB NIH HHS; LM05639/LM/NLM NIH HHS; M01 RR000865/RR/NCRR NIH HHS; M01 RR000865-33/RR/NCRR NIH HHS; N01 HD 023343/HD/NICHD NIH HHS; N01 HD023343/HD/NICHD NIH HHS; N01 NS092320/NS/NINDS NIH HHS; N01-MH90002/MH/NIMH NIH HHS; N01-NS-92314/NS/NINDS NIH HHS; N01-NS-92315/NS/NINDS NIH HHS; N01-NS-92316/NS/NINDS NIH HHS; N01-NS-92317/NS/NINDS NIH HHS; N01-NS-92319/NS/NINDS NIH HHS; N01-NS-92320/NS/NINDS NIH HHS; N01MH90002/MH/NIMH NIH HHS; N01NS92314/NS/NINDS NIH HHS; N01NS92315/NS/NINDS NIH HHS; N01NS92316/NS/NINDS NIH HHS; N01NS92317/NS/NINDS NIH HHS; N01NS92319/NS/NINDS NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-10/RR/NCRR NIH HHS; P50 AG016570/AG/NIA NIH HHS; P50 AG016570-03S1/AG/NIA NIH HHS; R01 EB007813/EB/NIBIB NIH HHS; R01 EB007813/EB/NIBIB NIH HHS; R01 EB007813-04/EB/NIBIB NIH HHS; R01 EB008281/EB/NIBIB NIH HHS; R01 EB008281/EB/NIBIB NIH HHS; R01 EB008281-14/EB/NIBIB NIH HHS; R01 EB008432/EB/NIBIB NIH HHS; R01 EB008432/EB/NIBIB NIH HHS; R01 EB008432-04/EB/NIBIB NIH HHS; R01 LM005639/LM/NLM NIH HHS; R01 LM005639-10/LM/NLM NIH HHS; R21 RR019771/RR/NCRR NIH HHS; R21 RR019771-02/RR/NCRR NIH HHS; RR019771/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813-05S5/RR/NCRR NIH HHS
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