| A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. | |
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MedLine Citation:
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PMID: 19160485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Myc-associated zinc-finger protein, Miz1, is a negative regulator of cell proliferation and induces expression of the cell-cycle inhibitors p15(Ink4b) and p21(Cip1). Here we identify the ribosomal protein L23 as a negative regulator of Miz1-dependent transactivation. L23 exerts this function by retaining nucleophosmin, an essential co-activator of Miz1 required for Miz1-induced cell-cycle arrest, in the nucleolus. Mutant forms of nucleophosmin found in acute myeloid leukaemia fail to co-activate Miz1 and re-localize it to the cytosol. As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest. |
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Authors:
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Michael Wanzel; Annika C Russ; Daniela Kleine-Kohlbrecher; Emanuela Colombo; Pier-Guiseppe Pelicci; Martin Eilers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature cell biology Volume: 10 ISSN: 1465-7392 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2009-01-22 Completed Date: 2009-02-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 1051-61 Citation Subset: IM |
Affiliation:
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Institute for Molecular Biology and Tumor Research (IMT), Emil-Mannkopff-Str.2, 35033 Marburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Cell Proliferation Feedback, Physiological Hela Cells Humans Models, Biological Mutant Proteins / metabolism Nuclear Proteins / metabolism* Protein Inhibitors of Activated STAT / antagonists & inhibitors, chemistry, metabolism* Protein Structure, Tertiary Proto-Oncogene Proteins c-myc / metabolism Rats Ribosomal Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Mutant Proteins; 0/Nuclear Proteins; 0/PIAS2 protein, human; 0/Protein Inhibitors of Activated STAT; 0/Proto-Oncogene Proteins c-myc; 0/Ribosomal Proteins; 0/ribosomal protein L17; 117896-08-9/nucleophosmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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