Document Detail

A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to biological imagings.
MedLine Citation:
PMID:  19166288     Owner:  NLM     Status:  MEDLINE    
A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.
Young-Keun Yang; Hyungseoph Jason Cho; Jihyun Lee; Injae Shin; Jinsung Tae
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  11     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  859-61     Citation Subset:  IM    
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
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MeSH Terms
Diagnostic Imaging
Fluorescent Dyes / chemical synthesis*,  chemistry,  diagnostic use*
Hydroxamic Acids / chemical synthesis*,  chemistry,  diagnostic use*
Hypochlorous Acid / chemistry*,  diagnostic use
Molecular Structure
Reactive Oxygen Species / chemistry,  diagnostic use
Rhodamines / chemical synthesis*,  chemistry,  diagnostic use*
Reg. No./Substance:
0/Fluorescent Dyes; 0/Hydroxamic Acids; 0/Reactive Oxygen Species; 0/Rhodamines; 7790-92-3/Hypochlorous Acid

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