Document Detail

The rhesus macaque pediatric SIV infection model - a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategies.
MedLine Citation:
PMID:  19149549     Owner:  NLM     Status:  MEDLINE    
Worldwide, the AIDS pandemic continues almost relentlessly. Women are now representing the fastest growing group of newly infected HIV-1 infected patients. The risk of mother-to-child-transmission (MTCT) of HIV-1 increases proportionally as many of these women are of childbearing age. The screening of pregnant women, the early diagnosis of HIV-1 infection, and the administration of antiretroviral therapy (ART) have helped to reduce MTCT significantly. However, this holds true only for developed countries. In many resource-poor countries, access to ART is limited, and breastfeeding, a major route of HIV-1 transmission, is essential to protect the infant from other infectious diseases preponderant in those geographic regions. HIV-1 infected children, in contrast to adult patients, have higher levels of virus replication that decline only slowly, and a subset progresses to AIDS within the first two years. Thus, it is imperative to understand pediatric HIV-1 pathogenesis to design effective prevention strategies and/or a successful pediatric HIV-1 vaccine. The review summarizes how MTCT of HIV-1 in humans can be modeled in the infant macaque model of SIV infection. Importantly, the infant macaque model of SIV infection provides the opportunity to study early virus-host interactions in multiple anatomic compartments. Furthermore, the review underlines the importance of evaluating SIV/HIV immune responses in the context of the normal developmental changes the immune system undergoes in the newborn. Thus, the pediatric SIV infection model provides a unique resource for preclinical studies of novel intervention therapies and vaccine strategies to stop MTCT of HIV-1.
Kristina Abel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current HIV research     Volume:  7     ISSN:  1873-4251     ISO Abbreviation:  Curr. HIV Res.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-02-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101156990     Medline TA:  Curr HIV Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2-11     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal*
HIV Infections / immunology,  pathology*,  prevention & control*,  transmission
Infectious Disease Transmission, Vertical / prevention & control*
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome / immunology,  pathology*,  prevention & control*,  transmission
Grant Support
P51 RR000169/RR/NCRR NIH HHS; P51 RR000169-475791/RR/NCRR NIH HHS; R01 DE019064/DE/NIDCR NIH HHS; R01 DE019064-01/DE/NIDCR NIH HHS

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