Document Detail


A rhesus macaque model of Streptococcus pneumoniae carriage.
MedLine Citation:
PMID:  21967372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease.
METHODS: We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F).
RESULTS: None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2weeks in 100% of the animals and 7weeks in more than 60%.
CONCLUSION: Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human-like carriage model.
Authors:
M T Philipp; L A Doyle; D S Martin; G B Plauché; K M Phillippi-Falkenstein; R P Bohm
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-04
Journal Detail:
Title:  Journal of medical primatology     Volume:  41     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-07-09     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  60-6     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA. Philipp@tulane.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchoalveolar Lavage Fluid / cytology,  microbiology
Carrier State / microbiology,  veterinary*
Colony Count, Microbial
Macaca mulatta / microbiology*
Male
Microbial Sensitivity Tests
Nasopharynx / microbiology,  radiography
Pneumococcal Infections / microbiology,  radiography,  veterinary*
Streptococcus pneumoniae / growth & development*
Grant Support
ID/Acronym/Agency:
P51 RR000164-42/RR/NCRR NIH HHS; P51 RR000164-43/RR/NCRR NIH HHS; P51-RR00164/RR/NCRR NIH HHS
Comments/Corrections

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