| The rhamnogalacturonan-II dimer decreases intestinal absorption and tissue accumulation of lead in rats. | |
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MedLine Citation:
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PMID: 10720178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rhamnogalacturonan-II dimer (dRG-II) forms strong complexes in vitro with lead (Pb) and other selected cations. We examined the in vivo bioavailability of Pb complexed with dRG-II and the effect of unleaded dRG-II on the intestinal absorption and tissue retention of Pb in rats. Forty male Wistar rats were divided into four groups. Each group consumed a purified control diet for 3 wk or the same diet supplemented with: i) 3 mg of Pb/kg, ii) 0.5 g of leaded dRG-II/kg, or iii) 0.5 g of leaded dRG-II/kg and 4.5 g of unleaded dRG-II/kg. The leaded dRG-II provided approximately 3 mg of Pb/kg of diet. A chemical balance study was conducted during the last 5 d of the 3-wk study, and blood and organs were sampled for Pb and mineral analyses. The apparent intestinal absorptions of Pb were 62.3, 15.2, 11.8 and -0.1%, and Pb balances were 1.9, 9.6, 5.6 and -0.2 microg/d for the control and the three experimental groups, respectively. The Pb complexed with dRG-II was less available than Pb acetate, as reflected by significantly lower blood and tissue Pb levels. The addition of unleaded dRG-II decreased the intestinal absorption and the tissue retention of Pb significantly. We further found that the apparent absorption and status of magnesium, zinc and iron were unaffected by Pb treatment or dRG-II addition. We conclude that dRG-II may be useful in decreasing toxicity related to chronic Pb exposure. Human studies will be necessary however, to further evaluate the clinical utility of this beneficial effect. |
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Authors:
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M Tahiri; P Pellerin; J C Tressol; T Doco; D Pépin; Y Rayssiguier; C Coudray |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 130 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-30 Completed Date: 2000-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 249-53 Citation Subset: IM |
Affiliation:
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Centre de Recherche en Nutrition Humaine d'Auvergne CRNH, Unité Maladies Métaboliques et Micronutriments, INRA, Saint Genès Champanelle, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Diet Eating / drug effects Growth / drug effects Intestinal Absorption / drug effects* Lead / pharmacokinetics* Male Metals / administration & dosage, blood Pectins / pharmacology* Rats Rats, Wistar Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Pectins; 0/rhamnogalacturonan II; 7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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