| A review on the vascular features of the hyperimmunoglobulin E syndrome. | |
| | |
MedLine Citation:
|
PMID: 19912258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autosomal recessive, autosomal dominant and the sporadic forms of hyperimmunoglobulin E syndrome (HIES) are multi-system disorders. Although HIES patients may present with cold abscesses, the vascular features of HIES are not well recognized. The objective of this review is to characterize the nature and spectrum of vascular abnormalities in HIES patients. Vascular abnormalities in HIES patients were reviewed with Medline and Google Scholar-based searches. In brief, the searches combined terms related to HIES with the terms related to vasculature. Furthermore, reference lists from the original studies and review papers identified were screened. There were vascular abnormalities in 25 patients with HIES. These abnormalities were identified as aneurysms (coronary, aortic, carotid and cerebral), pseudoaneurysms, congenital patent ductus venosus, superior vena cava syndrome, vasculitides, vascular ectasia, thrombosis and others. They may be congenital or acquired, in the veins and arteries, affecting both sexes. These abnormalities can be seen in all subtypes of HIES. They could be also fatal in children and adults. Limited pathological investigations revealed the presence of vasculitis. Three of the patients were found to have overlap diseases. In this review, the spectrum of vascular abnormalities in HIES are documented and discussed in detail for the first time. They highlight a previously under-recognized and potentially devastating complication of these disorders. These vascular abnormalities constitute one of the major clinical characteristics in HIES. The presence of hypereosinophilia, vasculitis and defective angiogenesis in HIES may contribute to the formation of vascular abnormalities in HIES. |
| | |
Authors:
|
H Yavuz; R Chee |
Related Documents
:
|
11453928 - Woolly hair, premature loss of teeth, nail dystrophy, acral hyperkeratosis and facial a... 9149998 - Transient bradycardia in a mouse model for the oromandibulofacial limb hypogenesis synd... 7426748 - The cytoskeleton in chediak-higashi syndrome fibroblasts. 20684458 - The role of screening electrocardiograms in the evaluation of rotc cadets applying for ... 15902518 - Concurrent occurrence of sweet's syndrome and erythema nodosum: an overlap in the spect... 2560098 - Copper deficiency in the mitochondria of cultured skin fibroblasts from patients with m... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-11-12 |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 159 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-01-22 Completed Date: 2010-02-17 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 238-44 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Selçuk University, Faculty of Medicine, Konya, Turkey. halukyavuz@mynet.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Blood Vessels / abnormalities* Child Child, Preschool Genetic Diseases, Inborn* / complications, genetics, metabolism, pathology, physiopathology Humans Job's Syndrome* / complications, genetics, metabolism, pathology, physiopathology Neovascularization, Pathologic* / etiology, genetics, metabolism, pathology, physiopathology Vascular Diseases* / etiology, genetics, metabolism, pathology |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epith...
Next Document: BRCA1 5272-1G>A and BRCA2 5374delTATG are founder mutations of high relevance for genetic counsel...