| A review on the use of hyaluronic acid in tympanic membrane wound healing. | |
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MedLine Citation:
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PMID: 22059535 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Tympanic membrane perforation represents a significant morbidity, especially if it occurs during a child's speech and language development. Recently, there has been an increased interest in hyaluronic-acid-related research and products as a potential therapeutic option for tympanic membrane perforation repair. Areas covered: This review describes the physical and chemical properties of hyaluronic acid and examines the role of hyaluronic acid in wound healing, in particular on the tympanic membrane. It also reviews the safety and efficacy of hyaluronic acid and its derivatives in animal studies as well as in clinical trials. Finally, it considers the potential future clinical applications in tympanic membrane perforation repair. Expert opinion: Hyaluronic acid has been found to accelerate tympanic membrane perforation closure, shorten the period of healing, produce a better quality neo-membrane and improve hearing. More importantly, hyaluronic acid is biodegradable, safe and biocompatible in the ear. Recently, there has been a trend towards the use of modified hyaluronic acid. However, there is a lack of higher-level evidence to support the use of hyaluronic acid in tympanic membrane perforations in the clinical setting. More large-scale randomised control trials are warranted before these bio-devices will be used routinely. |
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Authors:
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Bing Mei Teh; Yi Shen; Peter L Friedland; Marcus D Atlas; Robert J Marano |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: - ISSN: 1744-7682 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ear Sciences Centre, School of Surgery, The University of Western Australia, M507, 35 Stirling Highway, Nedlands, Western Australia, 6009 , Australia +61 8 9346 4606 ; +61 8 9346 2762 ; bm_teh@yahoo.co.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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