| A review of the use of ethyl glucuronide as a marker for ethanol consumption in forensic and clinical medicine. | |
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MedLine Citation:
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PMID: 19292025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethyl glucuronide (EtG) is a direct phase-II metabolite of ethanol formed through the UDP-glucuronosyl transferase catalyzed conjugation of ethanol with glucuronic acid. It has been detected in many antemortem and postmortem biological matrices using a variety of analytical methods. Due to its long urinary elimination time, detectability in hair, specificity for ethanol exposure, and low detection limits of assays, the use of EtG has been proposed as a marker of recent ethanol intake in a variety of clinical and legal settings, including medical monitoring for relapse, emergency department patient evaluation, postmortem assessments, and transportation accident investigation. However, challenges associated with factors such as establishing appropriate cut-off levels capable of distinguishing between drinking and nonbeverage sources of ethanol exposure, nonuniform laboratory reporting limits, sample stability, and microbial activity substantially complicate accurate interpretation of results. The following review briefly explores the history, utility, and limitations of EtG in contemporary medical and forensic practice. |
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Authors:
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Robert B Palmer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in diagnostic pathology Volume: 26 ISSN: 0740-2570 ISO Abbreviation: Semin Diagn Pathol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502262 Medline TA: Semin Diagn Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 18-27 Citation Subset: IM |
Affiliation:
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University of Colorado School of Medicine, Denver, Colorado, USA. RPalmer@Toxicologyassoc.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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blood* Alcoholism / blood, diagnosis Biological Markers / blood* Clinical Medicine / methods* Ethanol / pharmacokinetics* Female Forensic Medicine / methods* Glucuronates / blood* Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Glucuronates; 17685-04-0/ethyl glucuronide; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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