Document Detail

A review of sclerosing idiopathic orbital inflammation.
MedLine Citation:
PMID:  17700234     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Sclerosing idiopathic orbital inflammation is a rare, distinct subset of orbital inflammation. No consistent therapeutic regimen has been described and the majority of reports on this disease are case reports or small case series. This review looks at historical and current treatment modalities in an attempt to define the most current, effective management strategy for this disease. RECENT FINDINGS: Recently, the largest review to date of these patients was published, detailing clinical findings and responses to the various interventions. Two other case reports of patients who responded completely to therapy appeared in the literature. SUMMARY: Sclerosing idiopathic orbital inflammation is a rare disease with an unknown pathogenesis and poor prognosis. Current treatments are disappointing and often have little beneficial effect. There are anecdotal reports of success using combinations of immunosuppression, radiotherapy, and surgery, but a consistent, effective treatment course is lacking. Younger patients and those with a shorter duration of disease seem to have the best prognosis. Further research into the immunologic basis of the disease and a large, controlled study comparing the various sclerosing idiopathic orbital inflammation treatments are needed to determine the most effective treatment regimen.
Paul A Brannan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in ophthalmology     Volume:  18     ISSN:  1040-8738     ISO Abbreviation:  Curr Opin Ophthalmol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9011108     Medline TA:  Curr Opin Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-4     Citation Subset:  IM    
University of Cincinnati, Department of Ophthalmology, Cincinnati Eye Institute, Cincinnati, Ohio, USA.
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MeSH Terms
Diagnostic Techniques, Ophthalmological
Glucocorticoids / therapeutic use
Immunosuppressive Agents / therapeutic use
Orbital Pseudotumor / complications*,  diagnosis,  drug therapy
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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