Document Detail

A review of the role of stem cells in the development and treatment of glioma.
MedLine Citation:
PMID:  22527576     Owner:  NLM     Status:  MEDLINE    
The neurosurgical management of patients with intrinsic glial cancers is one of the most rapidly evolving areas of practice. This has been fuelled by advances in surgical technique not only in cytoreduction but also in drug delivery. Further innovation will depend on a deeper understanding of the biology of the disease and an appreciation of the limitations of current knowledge. Here we review the controversial topic of cancer stem cells applied to glioma to provide neurosurgeons with a working overview. It is now recognised that the adult human brain contains regionally specified cell populations capable of self-renewal that may contribute to tumour growth and maintenance following accumulated mutational change. Tumour cells adapted to maintain growth demonstrate some stem-like characteristics and as such constitute a legitimate therapeutic target. Cellular reprogramming technologies raise the potential of developing stem cells as novel surgical tools to target disease and possibly ameliorate some of the consequences of treatment. Achieving these goals remains a significant challenge to neurosurgical oncologists, not least in challenging how we think about treating brain cancer. This review will briefly examine our understanding of adult stem cells within the brain, the evidence that they contribute to the development of brain tumours as tumour-initiating cells, and the potential implications for therapy. It will also look at the role stem cells may play in the future management of glioma.
Richard M Heywood; Hani J Marcus; David J Ryan; Sara G M Piccirillo; Talal M Fael Al-Mayhani; Colin Watts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-20
Journal Detail:
Title:  Acta neurochirurgica     Volume:  154     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2013-02-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  951-69; discussion 969     Citation Subset:  IM    
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MeSH Terms
Brain Neoplasms / etiology*,  pathology*,  therapy
Cell Differentiation / physiology
Cell Transformation, Neoplastic / genetics,  pathology
Glioma / etiology,  physiopathology,  therapy*
Neoplastic Stem Cells / pathology
Stem Cell Transplantation / methods,  trends*
Grant Support
G108/507//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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