Document Detail


A review of the pharmacology and clinical uses of pimobendan.
MedLine Citation:
PMID:  22928748     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To review the pharmacology, research developments, and clinical uses of pimobendan
DATA SOURCES: Original research articles and clinical studies from 1984 to August 2011.
VETERINARY DATA SYNTHESIS: Pimobendan is approved for use in dogs for the treatment of congestive heart failure (CHF) secondary to chronic valvular heart disease (CVHD) and dilated cardiomyopathy (DCM). Expert-based veterinary guidelines recommend the use of pimobendan in the management of acute, hospital-based therapy for patients with CHF attributable to CVHD.
CONCLUSIONS: The use of pimobendan, an inodilator with phosphodiesterase 3 (PDE3) inhibitory and calcium-sensitizing properties, is regarded as a component of the standard of care in the management of dogs with CHF secondary to both DCM and CVHD. Further studies are warranted to confirm the safety and efficacy of pimobendan for the off-label use of this drug in asymptomatic CVHD, pulmonary arterial hypertension, asymptomatic myocardial diseases, CHF from all other causes and in cats with CHF.
Authors:
Kimberly L Boyle; Elizabeth Leech
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)     Volume:  22     ISSN:  1476-4431     ISO Abbreviation:  J Vet Emerg Crit Care (San Antonio)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101152804     Medline TA:  J Vet Emerg Crit Care (San Antonio)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-408     Citation Subset:  IM    
Copyright Information:
© Veterinary Emergency and Critical Care Society 2012.
Affiliation:
From the VCA All-Care Animal Referral Center, Fountain Valley, CA, 92708.
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