| A review of perineal talc exposure and risk of ovarian cancer. | |
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MedLine Citation:
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PMID: 7644715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors provide a detailed review of the events that led to the interest in talc as a possible ovarian carcinogen, the epidemiological studies published to date, and their perspective on the interpretation of the findings including potential limitations, biases, and issues surrounding the plausibility of a causal association. The authors conclude that the range of relative risk estimates from epidemiology, 1.0 to 1.8, is plausible, but that additional epidemiologic studies, especially prospective investigations are needed. In addition, clinicopathological studies are needed to confirm or deny the reports of talc embedded in human ovarian tissue and reports of talc migration through the human female reproductive tract. |
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Authors:
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B L Harlow; P A Hartge |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Regulatory toxicology and pharmacology : RTP Volume: 21 ISSN: 0273-2300 ISO Abbreviation: Regul. Toxicol. Pharmacol. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-09-21 Completed Date: 1995-09-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8214983 Medline TA: Regul Toxicol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 254-60 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Havard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asbestos / toxicity Bias (Epidemiology) Female Humans Ovarian Neoplasms / chemically induced*, epidemiology Perineum Risk Assessment Talc / adverse effects* |
| Chemical | |
Reg. No./Substance:
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1332-21-4/Asbestos; 14807-96-6/Talc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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