Document Detail


A review of perineal talc exposure and risk of ovarian cancer.
MedLine Citation:
PMID:  7644715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors provide a detailed review of the events that led to the interest in talc as a possible ovarian carcinogen, the epidemiological studies published to date, and their perspective on the interpretation of the findings including potential limitations, biases, and issues surrounding the plausibility of a causal association. The authors conclude that the range of relative risk estimates from epidemiology, 1.0 to 1.8, is plausible, but that additional epidemiologic studies, especially prospective investigations are needed. In addition, clinicopathological studies are needed to confirm or deny the reports of talc embedded in human ovarian tissue and reports of talc migration through the human female reproductive tract.
Authors:
B L Harlow; P A Hartge
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  21     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  IM    
Affiliation:
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Havard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Asbestos / toxicity
Bias (Epidemiology)
Female
Humans
Ovarian Neoplasms / chemically induced*,  epidemiology
Perineum
Risk Assessment
Talc / adverse effects*
Chemical
Reg. No./Substance:
1332-21-4/Asbestos; 14807-96-6/Talc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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