Document Detail


A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosa.
MedLine Citation:
PMID:  12769812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropeptides play an important role in the regulation of feeding behavior and obesity. The mechanisms for controlling food intake involve a complicated interplay between peripheral systems (including gustatory stimulation, gastrointestinal peptide secretion, and vagal afferent nerve responses) and central nervous system (CNS) neuropeptides and/or monoamines. These neuronal systems include neuropeptides (CRH, opioids, neuropeptide-Y (NPY) and peptide YY (PYY), vasopressin and oxytocin, CCK, and leptin) and monamines (serotonin, dopamine, norepinephrine). In addition to regulating eating behavior, a number of CNS neuropeptides participate in the regulation of neuroendocrine pathways. Thus, clinical studies have evaluated the possibility that CNS neuropeptide alterations may contribute to dysregulated secretion of the gonadal hormones, cortisol, thyroid hormones and growth hormone in the eating disorders. Most of the neuroendocrine and neuropeptide alterations apparent during symptomatic episodes of AN and BN tend to normalize after recovery. This observation suggests that most of the disturbances are consequences rather than causes of malnutrition, weight loss and/or altered meal patterns. Still, an understanding of these neuropeptide disturbances may shed light on why many people with AN or BN cannot easily "reverse" their illness and even after weight gain and normalized eating patterns, many individuals who have recovered from AN or BN have physiological, behavioral and psychological symptoms that persist for extended periods of time.
Authors:
Ursula F Bailer; Walter H Kaye
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug targets. CNS and neurological disorders     Volume:  2     ISSN:  1568-007X     ISO Abbreviation:  Curr Drug Targets CNS Neurol Disord     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-06-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101151150     Medline TA:  Curr Drug Targets CNS Neurol Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Affiliation:
University of Pittsburgh Medical Center, Anorexia and Bulimia Nervosa Research Module, Western Psychiatric Institute & Clinic, 3811 O'Hara Street, 600 Iroquois Building, Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / metabolism*,  physiopathology
Bulimia / metabolism*,  physiopathology
Humans
Neuropeptides / metabolism*
Neurosecretory Systems / metabolism*,  physiopathology
Chemical
Reg. No./Substance:
0/Neuropeptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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