Document Detail

A review of mortality due to Clostridium difficile infection.
MedLine Citation:
PMID:  20361997     Owner:  NLM     Status:  MEDLINE    
In this review we examine published literature to ascertain mortality in relation to Clostridium difficile infection (CDI) and the factors associated with mortality. In the 27 studies that had sufficient data, there were 10975 cases of CDI with great heterogeneity in the methods for reporting mortality. We calculated the overall associated mortality to be at least 5.99% within 3 months of diagnosis. The most important finding is that higher mortality is associated with advanced age, being 13.5% in patients over 80 years. Studies performed after 2000 had a significantly higher mortality than those before this date. We propose minimum standards for reporting mortality in future studies.
J A Karas; D A Enoch; S H Aliyu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-31
Journal Detail:
Title:  The Journal of infection     Volume:  61     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-07     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Clinical Microbiology & Public Health Laboratory, Health Protection Agency, Box 236, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
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MeSH Terms
Age Factors
Aged, 80 and over
Clostridium difficile / isolation & purification*
Enterocolitis, Pseudomembranous / mortality*
Middle Aged
Risk Factors
Young Adult
Comment In:
J Infect. 2013 Jan;66(1):111-3   [PMID:  23103665 ]

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