Document Detail


A review of mometasone furoate / formoterol in the treatment of asthma.
MedLine Citation:
PMID:  23363416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Asthma is a common chronic respiratory disease affecting the airways causing inflammation, airway hyperreactivity (AHR), and respiratory symptoms. Frequently, asthma can be effectively treated with inhaled corticosteroids (ICS) but in more severe cases additional drugs are required, such as long-acting β2-agonists (LABA). Mometasone furoate (MF) is a synthetic steroid exhibiting a strong affinity for the glucocorticoid receptor as well as a low bioavailability and a high plasma protein binding. In most cases, MF only requires once daily administration. Formoterol fumarate (F) is a full β2-agonist with a rapid onset and 12 h of duration.
AREAS COVERED: The present paper reviews the current knowledge of the novel combination of MF and F for the treatment of asthma. Furthermore, a description of the individual components is included.
EXPERT OPINION: At present, only few clinical studies of MF/F are available for review and more studies of MF/F efficacy are needed, especially comparative studies on other ICS/LABA drugs. However, it does not appear from the reviewed literature that MF/F or its individual components are inferior to other equivalent treatments.
Authors:
Christian Grabow Westergaard; Celeste Porsbjerg; Vibeke Backer
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-30
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  14     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-22     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-46     Citation Subset:  IM    
Affiliation:
Bispebjerg Hospital, Department of Respiratory Medicine L, Respiratory Research Unit, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. cgwestergaard@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Asthmatic Agents / administration & dosage,  pharmacology,  therapeutic use
Anti-Inflammatory Agents / administration & dosage,  pharmacology,  therapeutic use
Asthma / drug therapy*,  physiopathology
Bronchodilator Agents / administration & dosage,  pharmacology,  therapeutic use
Clinical Trials as Topic
Drug Combinations
Ethanolamines / administration & dosage,  pharmacology,  therapeutic use*
Humans
Pregnadienediols / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Bronchodilator Agents; 0/Drug Combinations; 0/Ethanolamines; 0/Pregnadienediols; 5ZZ84GCW8B/formoterol; 83919-23-7/mometasone furoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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