Document Detail


A review of the medical treatment of primary aldosteronism.
MedLine Citation:
PMID:  11288803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Use of the aldosterone-to-renin ratio (ARR) has suggested that at least one in 10 hypertensive subjects have primary aldosteronism (PA). There is thus a timely need to review the literature for effective drug therapies and to speculate on other therapeutic options by taking into account recent advances in understanding of the PA disease pathophysiological process. DATA SOURCE: A MEDLINE and EMBASE search of all articles published from the start of the databases until July 1999 and reviews of the bibliographies of textbooks. STUDY SELECTION: Primary research articles on the medical treatment of PA with emphasis on diagnosis, treatment option, drug dosage, therapeutic response and adverse drug effect. DATA EXTRACTION: Study design and quality were assessed. Relevant data on diagnostic methodology, drug usage and response were analysed and compared. DATA SYNTHESIS: A select number of subjects with aldosterone-producing adenoma (APA) can be expected to respond well to surgical treatment For the majority of PA cases especially subjects with idiopathic hyperaldosteronism (IHA), long-term medical treatment is now safe and feasible although no randomized controlled trials have been carried out to date. The best therapeutic response is obtained by directly antagonizing aldosterone at the receptor level using medium to low dose spironolactone and this response can be predicted by a raised ARR. The response to other potassium-sparing diuretics and calcium channel blockers are modest. IHA responds better than angiotensin II-unresponsive APA to angiotensin converting enzyme inhibitors and this may also be true with angiotensin II receptor blockers. The discovery of the aldosterone synthase gene opens up the possibility for gene therapy. CONCLUSION: The diagnosis of PA allows appropriate management with resultant blood pressure control in many hypertensive subjects who otherwise have resistant hypertension despite multiple drug therapy.
Authors:
P O Lim; W F Young; T M MacDonald
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  19     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-06-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-61     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff. limpo@cf.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / biosynthesis,  secretion
Aldosterone Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Calcium Channel Blockers / therapeutic use
Humans
Hyperaldosteronism / complications,  drug therapy*,  physiopathology,  surgery
Hypertension / drug therapy,  etiology,  physiopathology
Receptors, Mineralocorticoid / antagonists & inhibitors
Sodium Channel Blockers
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Receptors, Mineralocorticoid; 0/Sodium Channel Blockers; 52-39-1/Aldosterone
Comments/Corrections
Comment In:
J Hypertens. 2001 Mar;19(3):363-6   [PMID:  11288804 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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