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A review of mathematical models of cancer-immune interactions in the context of tumor dormancy.
MedLine Citation:
PMID:  23143981     Owner:  NLM     Status:  In-Data-Review    
The role of the immune system in tumor dormancy is now well established. In an immune-induced dormant state, potentially lethal cancer cells persist in a state where growth is restricted, to little or no increase, by the host's immune response. To describe this state in the context of cancer progression and immune response, basic temporal (spatially homogeneous) quantitative predator-prey constructs are discussed, along with some current and proposed augmentations that incorporate potentially significant biological phenomena such as the cancer cell transition to a quiescent state or the time delay in T-cell activation. Advances in cancer-immune modeling that describe complex interactions underlying the ability of the immune system to both promote and inhibit tumor growth are emphasized. Finally, the review concludes by discussing future mathematical challenges and their biological significance.
Kathleen P Wilkie
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  734     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-34     Citation Subset:  IM    
Center of Cancer Systems Biology, Steward Research & Specialty Projects Corp.,St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge St., Boston, MA, 02135, USA,
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