| A review of local anesthetic cardiotoxicity and treatment with lipid emulsion. | |
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MedLine Citation:
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PMID: 22915863 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular collapse from accidental local anesthetic toxicity is a rare but catastrophic complication of regional anesthesia. The long-acting amide local anesthetics bupivacaine, levobupivacaine and ropivacaine have differential cardiac toxicity, but all are capable of causing death with accidental overdose. In recent times, the chance discovery that lipid emulsion may improve the chance of successful resuscitation has lead to recommendations that it should be available in every location where regional anesthesia is performed. This review will outline the mechanisms of local anesthetic toxicity and the rationale for lipid emulsion therapy. |
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Authors:
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Emma Bourne; Christine Wright; Colin Royse |
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Publication Detail:
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Type: Journal Article Date: 2010-02-26 |
Journal Detail:
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Title: Local and regional anesthesia Volume: 3 ISSN: 1178-7112 ISO Abbreviation: Local Reg Anesth Publication Date: 2010 |
Date Detail:
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Created Date: 2012-08-23 Completed Date: 2012-10-02 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 101566276 Medline TA: Local Reg Anesth Country: New Zealand |
Other Details:
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Languages: eng Pagination: 11-9 Citation Subset: - |
Affiliation:
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Cardiovascular Therapeutics Unit, Department of Pharmacology, University of Melbourne. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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