Document Detail


A review of the irritable bowel syndrome investigation on epidemiology, pathogenesis and pathophysiology in China.
MedLine Citation:
PMID:  21443718     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Irritable bowel syndrome (IBS) is a highly prevalent functional disorder with poor understanding on its pathogenesis and pathology. China has huge amount of population and have a lot of literatures on IBS in Chinese publications. The aim of this article was to review the reported investigations on IBS in China and discuss the difference between China and other country.
METHODS: Literatures pertaining IBS epidemiology, pathogenesis and pathophysiology, which published in the high level journals in china and SCI journals after 1998 were reviewed.
RESULT: In the general health population, 5-6% meets the Rome II IBS criteria. Intestinal infection, food intolerance, genetic factor and psychological disturbance were responsible for the pathogenesis of IBS. In IBS patients, the impaired reaction to rectal distension, abnormal gastrointestinal motility, impaired autonomic nerve function, weakened colon epithelium connection, altered cerebral nuclei activation were the main pathophysiological findings.
CONCLUSION: Comparing to the findings from other area, literatures from China provided more evidences on epidemiological data of IBS in China, post-infection IBS, visceral hypertension and gastrointestinal motility abnormalities in IBS. This detailed literature review may help the understanding and promoting the future studies on IBS.
Authors:
Jinsong Liu; Xiaohua Hou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  26 Suppl 3     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  IM    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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