Document Detail


A review of the investigational antiarrhythmic agent dronedarone.
MedLine Citation:
PMID:  17495254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arrhythmias are a major cause of morbidity and mortality, and atrial fibrillation is the most widespread disorder of cardiac rhythm. Amiodarone is an effective antiarrhythmic agent that has been in clinical use for about 20 years. It is effective for multiple types of arrhythmias, including atrial fibrillation, and has a low incidence of cardiac adverse events, including Torsade de Pointes. It has many noncardiac adverse effects that are serious and limit its long-term use. Dronedarone is an investigational antiarrhythmic agent that is designed to have similar cardiac effects to amiodarone but with fewer adverse effects. This review presents some of the animal and human studies that evaluate the effects of dronedarone.
Authors:
Mohammad J Tafreshi; Joie Rowles
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology and therapeutics     Volume:  12     ISSN:  1074-2484     ISO Abbreviation:  J. Cardiovasc. Pharmacol. Ther.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9602617     Medline TA:  J Cardiovasc Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-26     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Practice, College of Pharmacy-Glendale, Midwestern University, 19555 North 59th Avenue, Glendale, AZ 85308, USA.
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MeSH Terms
Descriptor/Qualifier:
Amiodarone / analogs & derivatives*,  chemistry,  pharmacology,  therapeutic use
Animals
Anti-Arrhythmia Agents / chemistry,  pharmacology,  therapeutic use*
Atrial Fibrillation / drug therapy,  physiopathology
Clinical Trials as Topic
Drugs, Investigational / pharmacology,  therapeutic use*
Humans
Ion Channels / physiology*
Membrane Potentials / drug effects
Molecular Structure
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Drugs, Investigational; 0/Ion Channels; 0/dronedarone; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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