Document Detail

A review of the haemodynamic effects of labetalol in man.
MedLine Citation:
PMID:  7093099     Owner:  NLM     Status:  MEDLINE    
1 Labetalol at a dose of 800 to 1600 mg daily inhibited isoprenaline-induced tachycardia and phenylephrine-induced elevation in arterial pressure in hypertensive subjects. The beta-adrenoreceptor effect was four times more potent than the alpha-adrenoreceptor effect. 2 Isoprenaline-induced tachycardia was more effectively blocked than isoprenaline-induced inotropism, thereby raising the possibility of a subselective effect on cardiac beta-adrenoceptors. 3 Labetalol reduced blood pressure in hypertensive subjects with no change in cardiac output in the supine or upright position and with marked inhibition of the heart rate and blood pressure response to treadmill exercise. 4 Labetalol administered in single doses to patients with stable, treated congestive heart failure impaired blood pressure support during exercise. 5 The unique adrenoceptor and haemodynamic effects of labetalol make it a potentially attractive drug for management of hypertension and other cardiovascular disorders.
J N Cohn; J Mehta; G S Francis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  13     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19S-26S     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Ethanolamines / pharmacology*
Heart Failure / drug therapy
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy
Labetalol / pharmacology*,  therapeutic use
Myocardial Contraction / drug effects
Receptors, Adrenergic / drug effects
Time Factors
Reg. No./Substance:
0/Ethanolamines; 0/Receptors, Adrenergic; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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