| A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro. | |
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MedLine Citation:
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PMID: 15094208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus. It is also over-expressed in many carcinomas. The receptor appears to remain membrane bound but cycles between the cell surface and an internal compartment. Its localization to detergent resistant membranes (lipid rafts) may be important to its cycling and indeed putative function to conserve folate in selected body compartments. Agents that disrupt the actin cytoskeleton such as cytochalasin D as well as phorbol myristic acid effect cycling of the receptor. The monkey kidney cell line, MA104, has proved to be a useful model for studying FRalpha cycling and 5-methyltetrahydrofolate accumulation. This chapter reviews much of this work and compares and contrasts it to studies of other cells, both normal and malignant. |
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Authors:
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Barton A Kamen; Angel K Smith |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 56 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-11-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1085-97 Citation Subset: IM |
Affiliation:
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Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 80901, USA. kamenba@umdnj.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Carrier Proteins / chemistry, metabolism* Cell Line Cytoplasm / metabolism* Folic Acid / chemistry*, metabolism* Humans Receptors, Cell Surface / chemistry, metabolism* Tetrahydrofolates / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Receptors, Cell Surface; 0/Tetrahydrofolates; 0/folate-binding protein; 134-35-0/5-methyltetrahydrofolate; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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