| A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen. | |
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MedLine Citation:
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PMID: 16158390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The National Toxicology Program (NTP) is responsible for providing comprehensive toxicology evaluations of substances, while at the same time incorporating approaches to reduce, refine or replace laboratory animals in routine toxicity/carcinogenicity studies. Consistent with this, a series of metabolism studies in rodents and human liver slices, electron spin resonance spectroscopy (ESR) studies, short-term dermal toxicity studies in rodents, and acute bone marrow micronucleus studies in mice were performed on diazoaminobenzene (DAAB, also known as 1,3-diphenyltriazine). These studies demonstrated that DAAB is metabolized and shares similar genotoxic and toxicological properties to the known human carcinogen, benzene, and the known rodent carcinogen, aniline. These data were used to evaluate the potential carcinogenicity of DAAB without doing a 2-year rodent bioassay. Based on this analysis, DAAB was predicted to be carcinogenic if evaluated in a 2-year rodent bioassay. These data were evaluated to support listing DAAB in the NTP Report on Carcinogens as a substance 'reasonably anticipated to be a human carcinogen'. The purpose of this article is to review the data developed for predicting the carcinogenicity of DAAB. |
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Authors:
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Nancy R Bordelon; Rajendra Chhabra; John R Bucher |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 25 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2006-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 514-21 Citation Subset: IM |
Copyright Information:
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Published in 2005 by John Wiley & Sons, Ltd. |
Affiliation:
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National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Aniline Compounds / urine Animals Biological Assay / methods Bone Marrow Cells / drug effects Carcinogenicity Tests Carcinogens / administration & dosage, toxicity* Cytochrome P-450 Enzyme System / metabolism Electron Spin Resonance Spectroscopy Humans Liver / drug effects, metabolism Mice Micronucleus Tests Mutagenicity Tests Rats Salmonella typhimurium / drug effects, genetics Skin Absorption Skin Diseases / chemically induced, urine Triazenes / administration & dosage, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Aniline Compounds; 0/Carcinogens; 0/Triazenes; 136-35-6/1,3-diphenyl-1-triazene; 62-53-3/aniline; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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