| A review of electrocardiography in the high altitude environment. | |
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MedLine Citation:
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PMID: 20367489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An ascent to altitude places considerable demands on the cardiovascular system. Changes in the rate, rhythm, and morphology of the electrocardiogram reflect the fall in the partial pressure of inspired oxygen (PiO2) and the adaptive responses that the human body makes. The effect of hypoxia on the autonomic nervous system results in changes to the heart rate during rest and exercise. Although this is raised during rest and submaximal exercise, maximal heart rate at altitude is reduced as a result of changes in parasympathetic activity. Hypoxic pulmonary vasoconstriction leads to a rise in pulmonary artery pressure and morphological changes on the electrocardiogram. Right axis deviation, right bundle branch block, and changes to P and T wave amplitudes are commonly found on ascent and resolve only after a return to low altitude. Although atrial and ventricular ectopic activity is also common, tachyarrhythmias are rare in healthy individuals. However, in those with significant cardiac disease, the hypoxic environment can be hazardous, exposing individuals to ischemia and the risk of sudden cardiac death. |
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Authors:
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Jeremy S Windsor; George W Rodway; Hugh E Montgomery |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: High altitude medicine & biology Volume: 11 ISSN: 1557-8682 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 51-60 Citation Subset: IM; S |
Affiliation:
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UCL Centre for Altitude, Space and Extreme Environment Medicine, Institute of Human Health and Performance, University College London, London, UK. jswindsor@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Adaptation, Physiological Altitude* Anoxia / physiopathology Apnea / physiopathology Arrhythmias, Cardiac / physiopathology Bundle-Branch Block / physiopathology Cardiac Output / physiology Coronary Circulation / physiology Electrocardiography* Heart Rate / physiology Humans Oxygen / blood Respiration Sleep / physiology |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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