Document Detail

A review of eclampsia in Melbourne: 1978-1992.
MedLine Citation:
PMID:  8883747     Owner:  NLM     Status:  MEDLINE    
A retrospective review of all cases of eclampsia diagnosed at 3 obstetric teaching hospitals in Melbourne from January, 1978 to December, 1992 was undertaken. Ninety cases were identified; there were 5 maternal deaths and 17 perinatal deaths. Severe maternal morbidity such as pulmonary oedema, acute renal failure or HELLP syndrome was found in 26%. Significant maternal thrombocytopenia (< 100 x 10(9)/L) was found in 50% and 35% had abnormal maternal liver function tests. Forty six women received magnesium sulphate for treatment of eclampsia and of these 3 had further seizures compared to 4 of 18 who received phenytoin (odds ratio 0.24 (0.04-1.52) X2, p = 0.09). Eclampsia remains a significant complication of pregnancy with high maternal and perinatal mortality and morbidity. Results of this study show a trend that is in agreement with recent randomized controlled trials which demonstrate a reduced incidence of seizures and maternal and fetal complications with the use of magnesium sulphate. The results of these recent trials suggest that magnesium sulphate should be the drug of choice in the prevention and treatment of eclampsia.
R Cincotta; A Ross
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  36     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  264-7     Citation Subset:  IM    
Department of Perinatal Medicine, Royal Women's Hospital, Melbourne, Victoria.
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MeSH Terms
Anticonvulsants / therapeutic use
Australia / epidemiology
Eclampsia / complications,  drug therapy,  epidemiology*
HELLP Syndrome / diagnosis,  epidemiology
Magnesium Sulfate / therapeutic use
Retrospective Studies
Reg. No./Substance:
0/Anticonvulsants; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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