Document Detail

A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors.
MedLine Citation:
PMID:  16049800     Owner:  NLM     Status:  MEDLINE    
Maternal dietary exposure to N-nitroso compounds (NOC) or to their precursors during pregnancy has been associated with risk of childhood brain tumors. Cured meat is one source of exposure to dietary NOC and their precursors. Most epidemiological studies that have examined the role of maternal consumption of cured meats during pregnancy have found a significant positive association between maternal intake of cured meat and the risk of childhood brain tumor (CBT). NOC consist of two main groups, N-nitrosamines and N-nitrosamides. The carcinogenicity profiles of NOC suggest that N-nitrosamides rather than N-nitrosamines are the compounds that may be associated with CBT and that they should be investigated more closely in epidemiological studies. We present a review of the chemical and carcinogenic properties of NOC in connection with the findings of case-control studies. This approach may be helpful in determining the essential information that must be collected in future epidemiological studies on CBT.
Marion Dietrich; Gladys Block; Janice M Pogoda; Patricia Buffler; Stephen Hecht; Susan Preston-Martin
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  16     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-28     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  619-35     Citation Subset:  IM    
School of Public Health, University of California-Berkeley, Berkeley, CA 94720-7360, USA.
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MeSH Terms
Brain Neoplasms / epidemiology*,  etiology
Maternal Exposure
Meat Products / adverse effects
Nitrosamines / adverse effects*
Nitroso Compounds / adverse effects*
Prenatal Exposure Delayed Effects*
Risk Factors
Reg. No./Substance:
0/Nitrosamines; 0/Nitroso Compounds; 0/nitrosamides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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