Document Detail

A review of continuation electroconvulsive therapy: application, safety, and efficacy.
MedLine Citation:
PMID:  20805727     Owner:  NLM     Status:  MEDLINE    
Electroconvulsive therapy (ECT) is a neurostimulation therapeutic intervention that is highly effective and frequently used to treat certain psychiatric conditions, particularly major depressive disorder. Despite its high efficacy, a major limitation of ECT is the significant rate at which patients relapse after treatment. Providing additional ECT treatments after completion of a short-term course of ECT, referred to as continuation ECT (C-ECT), is a strategy used to reduce the risk of relapse. Specifically, C-ECT involves the administration of additional ECT treatments during the 6-month period after remission. This article summarizes the available literature regarding C-ECT including indication for use, patient selection, treatment guidelines/parameters, and safety. The efficacy of C-ECT is also discussed, with a focus on major depressive disorder and schizophrenia. On the basis of the current literature, indications for use and patient selection for C-ECT are predominately similar to those for a short-term ECT course. The treatment guidelines/parameters for C-ECT are recommended to be consistent with the parameters used to achieve remission, with the exception of greater intertreatment intervals during C-ECT. Although adverse cognitive effects can occur during C-ECT, the risk and severity of cognitive impairment are generally low, possibly because of the greater intertreatment intervals. Most research supports the use of C-ECT to prolong remission; however, methodologic limitations mitigate firm conclusions and generalizability of these findings. Nonetheless, the available evidence supports the use of C-ECT as a safe and effective method in relapse prevention.
Kenneth Trevino; Shawn M McClintock; Mustafa M Husain
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of ECT     Volume:  26     ISSN:  1533-4112     ISO Abbreviation:  J ECT     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-28     Revised Date:  2012-01-06    
Medline Journal Info:
Nlm Unique ID:  9808943     Medline TA:  J ECT     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-95     Citation Subset:  IM    
Neurostimulation Research Laboratory, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Electroconvulsive Therapy / methods*,  standards*
Mental Disorders / therapy*
Treatment Outcome
Comment In:
J ECT. 2011 Dec;27(4):339-40   [PMID:  22124219 ]

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