| A review of clinical and laboratory findings and treatment of tumor lysis syndrome. | |
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MedLine Citation:
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PMID: 12809731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute tumor lysis syndrome (TLS) has started to be considered a separate entity or condition associated with bulk tumor treatment. TLS is described as the biochemical disturbances associated with rapid destruction of tumor cells with subsequent synchronised massive release of cellular breakdown products sufficient to overwhelm excretory mechanisms and the body's normal reutilization capacity. The cardinal signs of TLS are: hyperkalemia, hyperphosphatemia, hypocalcemia and hyperuricemia. This review comprehensively discusses the differential diagnosis, pathophysiology and clinical features, possible causal indications for laboratory monitoring and treatment options of TLS. |
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Authors:
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Aysegul Akbay Yarpuzlu |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 333 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-17 Completed Date: 2004-02-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
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Faculty of Health Education, Ankara University, Fatih Cad No. 197, Cift Asfalt-Keçiören, Ankara, Turkey. akbay@dialup.ankara.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Humans Hyperkalemia / etiology, therapy Hyperuricemia / etiology, therapy Hypocalcemia / etiology, therapy Kidney Failure / etiology, therapy Lymphoma / physiopathology Neoplasms / drug therapy, physiopathology* Phosphorus Metabolism Disorders / etiology, therapy Risk Factors Tumor Lysis Syndrome / etiology, physiopathology*, prevention & control |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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