Document Detail


A review of clinical and laboratory findings and treatment of tumor lysis syndrome.
MedLine Citation:
PMID:  12809731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute tumor lysis syndrome (TLS) has started to be considered a separate entity or condition associated with bulk tumor treatment. TLS is described as the biochemical disturbances associated with rapid destruction of tumor cells with subsequent synchronised massive release of cellular breakdown products sufficient to overwhelm excretory mechanisms and the body's normal reutilization capacity. The cardinal signs of TLS are: hyperkalemia, hyperphosphatemia, hypocalcemia and hyperuricemia. This review comprehensively discusses the differential diagnosis, pathophysiology and clinical features, possible causal indications for laboratory monitoring and treatment options of TLS.
Authors:
Aysegul Akbay Yarpuzlu
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  333     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2004-02-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Affiliation:
Faculty of Health Education, Ankara University, Fatih Cad No. 197, Cift Asfalt-Keçiören, Ankara, Turkey. akbay@dialup.ankara.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Humans
Hyperkalemia / etiology,  therapy
Hyperuricemia / etiology,  therapy
Hypocalcemia / etiology,  therapy
Kidney Failure / etiology,  therapy
Lymphoma / physiopathology
Neoplasms / drug therapy,  physiopathology*
Phosphorus Metabolism Disorders / etiology,  therapy
Risk Factors
Tumor Lysis Syndrome / etiology,  physiopathology*,  prevention & control

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