| A review of chemically-induced alterations in thyroid and vitamin A status from field studies of wildlife and fish. | |
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MedLine Citation:
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PMID: 11085423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews 22 published field studies that have found an association between exposure to environmental contaminants and alterations in thyroid gland structure, circulating thyroid hormones and vitamin A (retinoid) status in free-ranging populations of wildlife and fish. Vitamin A and thyroid hormones play critical roles during development, growth and function 'throughout life. Studies of captive wildlife and laboratory studies support a relationship between alterations in thyroid hormones and vitamin A status and exposure to dioxins, furans, and planar polychlorinated biphenyls, which bind to the aryl hydrocarbon receptor. Some studies have found adverse health effects in wildlife associated with exposure to polyhalogenated aromatic hydrocarbons and altered thyroid and retinoid status including: decreased reproductive success, immune system changes, dermatologic abnormalities and developmental deformities. A direct causal relationship between these effects and thyroid and retinoid changes has not been demonstrated. Field researchers studying the responses to these synthetic chemicals in wildlife and fish should include measurement of thyroid hormones and retinoids and histological examination of the thyroid gland in their study design as biomarkers of exposure to these chemicals in the environment. |
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Authors:
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R M Rolland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of wildlife diseases Volume: 36 ISSN: 0090-3558 ISO Abbreviation: J. Wildl. Dis. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-01-03 Completed Date: 2001-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244160 Medline TA: J Wildl Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 615-35 Citation Subset: IM |
Affiliation:
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Center for Conservation Medicine, Tufts University School of Veterinary Medicine, Massachusetts 01536, USA. rrolland@infonet.tufts.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Wild* Bird Diseases / chemically induced* Cetacea* Dioxins / toxicity Environmental Pollutants / adverse effects* Female Fish Diseases / chemically induced* Hydrocarbons, Halogenated Male Pinnipedia Polychlorinated Biphenyls / toxicity Polycyclic Hydrocarbons, Aromatic / toxicity Retinoids / metabolism Thyroid Diseases / chemically induced, veterinary* Thyroid Gland / pathology, physiopathology Thyroid Hormones / chemistry, physiology Vitamin A / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Dioxins; 0/Environmental Pollutants; 0/Hydrocarbons, Halogenated; 0/Polychlorinated Biphenyls; 0/Polycyclic Hydrocarbons, Aromatic; 0/Retinoids; 0/Thyroid Hormones; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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