Document Detail

A review of chemical agents in the pharmacotherapy of addiction.
MedLine Citation:
PMID:  12369879     Owner:  NLM     Status:  MEDLINE    
Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol, cocaine and opiates. Other alkaloids from Tabernanthe iboga, such as ibogamine and tabernanthine, provide insight into the structure activity relationship at the different receptors believed to be involved in addiction. The synthetic iboga alkaloid congener, 18-MC, also shows potential as an anti-addictive agent without the hallucinogenic effects of ibogaine. Additionally, acamprosate, BP 897, GBR12909, lofexidine and memantine have shown promising results in the treatment of addiction. All of these leads provide a start for the medicinal chemist to design anti-addictive agents, since currently no drugs are approved in the U.S. for the treatment of addictions to cocaine, methamphetamine, other stimulants or PCP.
M S Levi; R F Borne
Related Documents :
15464129 - Genetic and genomic approaches to reward and addiction.
16173879 - Does habituation play a role in drug habit? comment on mcsweeney, murphy, and kowal (20...
7625519 - The rise of the modern addict.
16402099 - 75 years of opioid research: the exciting but vain quest for the holy grail.
16842359 - Developmental regulator le.cdc5 of the mushroom lentinula edodes: analyses of its amoun...
8556969 - Craving and drug reward: a comparison of methadone and clonidine in detoxifying opiate ...
2095299 - Psychobehavioral disturbance in epileptic children.
11501989 - Investigational antifungal agents.
19622129 - Delivery of a classical antihypertensive agent through the skin by chemical enhancers a...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  9     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-08     Completed Date:  2003-03-13     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1807-18     Citation Subset:  IM    
Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcohol Deterrents / chemistry
Alkaloids / chemistry,  therapeutic use
Excitatory Amino Acid Antagonists / chemistry
Narcotic Antagonists / chemistry
Neurotransmitter Agents / chemistry
Structure-Activity Relationship
Substance-Related Disorders / drug therapy*
Reg. No./Substance:
0/Alcohol Deterrents; 0/Alkaloids; 0/Excitatory Amino Acid Antagonists; 0/Narcotic Antagonists; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The cyanobacterial origin of potent anticancer agents originally isolated from sea hares.
Next Document:  Reliability of logP predictions based on calculated molecular descriptors: a critical review.