Document Detail


A review of chemical agents in the pharmacotherapy of addiction.
MedLine Citation:
PMID:  12369879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol, cocaine and opiates. Other alkaloids from Tabernanthe iboga, such as ibogamine and tabernanthine, provide insight into the structure activity relationship at the different receptors believed to be involved in addiction. The synthetic iboga alkaloid congener, 18-MC, also shows potential as an anti-addictive agent without the hallucinogenic effects of ibogaine. Additionally, acamprosate, BP 897, GBR12909, lofexidine and memantine have shown promising results in the treatment of addiction. All of these leads provide a start for the medicinal chemist to design anti-addictive agents, since currently no drugs are approved in the U.S. for the treatment of addictions to cocaine, methamphetamine, other stimulants or PCP.
Authors:
M S Levi; R F Borne
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  9     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-08     Completed Date:  2003-03-13     Revised Date:  2007-02-12    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1807-18     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Deterrents / chemistry
Alkaloids / chemistry,  therapeutic use
Excitatory Amino Acid Antagonists / chemistry
Humans
Narcotic Antagonists / chemistry
Neurotransmitter Agents / chemistry
Structure-Activity Relationship
Substance-Related Disorders / drug therapy*
Chemical
Reg. No./Substance:
0/Alcohol Deterrents; 0/Alkaloids; 0/Excitatory Amino Acid Antagonists; 0/Narcotic Antagonists; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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