| A review of chemical agents in the pharmacotherapy of addiction. | |
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MedLine Citation:
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PMID: 12369879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol, cocaine and opiates. Other alkaloids from Tabernanthe iboga, such as ibogamine and tabernanthine, provide insight into the structure activity relationship at the different receptors believed to be involved in addiction. The synthetic iboga alkaloid congener, 18-MC, also shows potential as an anti-addictive agent without the hallucinogenic effects of ibogaine. Additionally, acamprosate, BP 897, GBR12909, lofexidine and memantine have shown promising results in the treatment of addiction. All of these leads provide a start for the medicinal chemist to design anti-addictive agents, since currently no drugs are approved in the U.S. for the treatment of addictions to cocaine, methamphetamine, other stimulants or PCP. |
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Authors:
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M S Levi; R F Borne |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 9 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-08 Completed Date: 2003-03-13 Revised Date: 2007-02-12 |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1807-18 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Deterrents
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chemistry Alkaloids / chemistry, therapeutic use Excitatory Amino Acid Antagonists / chemistry Humans Narcotic Antagonists / chemistry Neurotransmitter Agents / chemistry Structure-Activity Relationship Substance-Related Disorders / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Alcohol Deterrents; 0/Alkaloids; 0/Excitatory Amino Acid Antagonists; 0/Narcotic Antagonists; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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