Document Detail


A review of canine pseudocyesis.
MedLine Citation:
PMID:  11928922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this article is to review the most relevant features of the physiology, clinical signs, diagnosis, treatment and prevention of canine pseudocyesis (PSC). This is a physiological syndrome, characterized by clinical signs such as: nesting, weight gain, mammary enlargement, lactation and maternal behaviour, which appears in non-pregnant bitches at the end of metaoestrus. PSC is a frequent finding in domestic dogs. Although it is generally admitted that prolactin (PRL) plays a central role in the appearance of PSC, its precise aetiophysiology is not completely understood yet. A number of clinical studies suggest that at some point of metaoestrus circulating PRL levels rise in overtly pseudopregnant bitches. Individual differences in sensitivity to PRL as well as the existence of molecular variants of canine PRL with different bioactivity versus immunoreactivity ratios may help clarify the aetiopathology of PSC. Diagnosis of PSC is based on the presence of typical clinical signs in metaoestrous non-pregnant bitches. Considering that PSC is a self limiting physiological state, mild cases usually need no treatment. Discouraging maternal behaviour and sometimes fitting Elizabethan collars to prevent licking of the mammary glands may suffice in these cases. Sex steroids (oestrogens, progestins and androgens) have been traditionally used to treat PSC but the side-effects usually outweigh the benefits of these medications. Inhibition of PRL release by ergot derivatives [bromocriptine (10-100 microg/kg per day for 10-14 days], cabergoline (5 microg/kg per day during 5-10 days), metergoline (0.2 mg/kg per day during 8-10 days) has proved to be effective for the treatment of canine PSC. Although some of these ergot derivatives present some untoward side-effects, they are transient and can usually be managed. Predisposed bitches not intended for breeding should be spayed as ovariectomy is the only permanent preventive measure.
Authors:
C Gobello; R L de la Sota; R G Goya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  36     ISSN:  0936-6768     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-04-03     Completed Date:  2002-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
Affiliation:
Institute of Theriogenology, College of Veterinary Science, National University of La Plata, Argentina. cgobello@fcv.medvet.unlp.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Dog Diseases / diagnosis,  physiopathology*,  therapy
Dogs
Estrus / blood,  physiology
Female
Prolactin / blood
Pseudopregnancy / diagnosis,  physiopathology,  therapy,  veterinary*
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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