| A review of anti-D treatment of childhood idiopathic thrombocytopenic purpura. | |
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MedLine Citation:
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PMID: 16933265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of childhood idiopathic thrombocytopenic purpura is still an area of controversy. We reviewed the literature on anti-D treatment. Most studies used intravenous anti-D. Single doses of 50 microg/kg increased the platelet count to >or=20x10(9)/L in 70% of the children within 3 days. Intravenous anti-D seems safe in classic childhood ITP although hemolysis and occasionally renal failure may be of concern. A few studies reported intramuscularly or subcutaneously administered anti-D. Further studies on the optimal dose and route of administration of anti-D are warranted. |
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Authors:
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Mimi Kjaersgaard; Henrik Hasle |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 47 ISSN: 1545-5009 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-08-31 Completed Date: 2006-11-28 Revised Date: 2009-01-12 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 717-20 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, Aarhus University, Skejby Hospital, Denmark. mimi.kjaersgaard@ki.au.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Dose-Response Relationship, Drug Humans Isoantibodies / administration & dosage, adverse effects, therapeutic use* Platelet Count Purpura, Thrombocytopenic, Idiopathic / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Isoantibodies; 0/RHO(D) antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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