Document Detail


A review: the agents and actions of sympathetic nerve and catecholamine inhibition of gastric mucosal function.
MedLine Citation:
PMID:  785979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the sympathetic nerve supply to the gastric mucosa in gastric physiology is discussed. It is concluded that they are inhibitory to gastric acid secretion, mucosal blood flow, pepsin secretion, gastric oxygen consumption and that these nerves also decrease the serum gastrin concentration. Sympathetic nerve stimulation always reduces the mucosal blood flow and it is suggested therefore, that the inhibition of gastric secretion could be secondary to vasoconstriction mediated by noradrenaline release. The evidence for these conclusions is considered alongside the available histological evidence. It is concluded that the remaining hurdle is to place these phenomena within our knowledge of gastric physiology.
Authors:
D J Sanders
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Agents and actions     Volume:  6     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / antagonists & inhibitors*
Cats
Electric Stimulation
Gastric Juice / secretion
Gastric Mucosa / blood supply,  drug effects,  innervation,  physiology*,  secretion
Guinea Pigs
Neurons, Efferent / physiology
Pepsin A / secretion
Rats
Regional Blood Flow / drug effects
Splanchnic Nerves / physiology
Sympathetic Nervous System / physiology*
Chemical
Reg. No./Substance:
0/Catecholamines; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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