Document Detail

A review of adsorption of amino acids on minerals: was it important for origin of life?
MedLine Citation:
PMID:  15309580     Owner:  NLM     Status:  MEDLINE    
Minerals more readily adsorb amino acids with charged R groups than uncharged R groups, so that the incorporation of amino acids with charged R groups into peptides would be more frequent than for amino acids with uncharged R groups. However, 74% of the amino acids in the proteins of modern organisms contain uncharged R groups. Thus, what could have been the mechanisms that produced peptides/proteins with more amino acids with uncharged R groups than precursors with charged R groups? Should we expect the composition of amino acids adsorbed on minerals to be similar to those of present proteins? Was the adsorption of amino acids on minerals important for the origin of life? The lipid world offers an alternative view of origin of life. Liposomes contributed to elongation of peptides as well as select hydrophobic amino acids and peptides. These experiments could be showing the mechanism, which hydrophobic amino acids have been selected. However, liposomes have no influence on the stereoselectivity in the oligomerization of amino acids. In the present paper, several other mechanisms are also discussed that could produce peptides with a greater proportion of amino acids with uncharged R groups.
D A M Zaia
Publication Detail:
Type:  Journal Article; Review     Date:  2004-07-19
Journal Detail:
Title:  Amino acids     Volume:  27     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2005-04-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Departamento de Química-CCE, Universidade Estadual de Londrina, Londrina-PR, Brazil.
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MeSH Terms
Amino Acids / chemistry*
Earth (Planet)
Liposomes / metabolism
Minerals / chemistry*
Peptide Biosynthesis
Peptides / chemistry
Reg. No./Substance:
0/Amino Acids; 0/Liposomes; 0/Minerals; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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