Document Detail


A reversible preparation for observing the behavior of fetal rats in utero: spinal anesthesia with lidocaine.
MedLine Citation:
PMID:  3737724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A technique is described whereby lidocaine with epinephrine is injected into the spinal cord of the pregnant rat to produce reversible spinal anesthesia. This technique is useful for preparing pregnant females to study the spontaneous behavior of their fetuses in utero. Comparison of this procedure with an alternative, but irreversible, spinal preparation (chemomyelotomy) indicates that reversible lidocaine anesthesia does not differentially influence the activity of rat fetuses on Day 19 of gestation. This procedure will enable repeated observation of the same fetus at various stages of gestation and provide a means for the longitudinal study of behavioral development across the transition from prenatal to postnatal life.
Authors:
W P Smotherman; S R Robinson; B J Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  37     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1986  
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Spinal*
Animals
Behavior, Animal* / drug effects
Embryonic and Fetal Development* / drug effects
Female
Fetal Movement / drug effects
Gestational Age
Lidocaine*
Models, Biological
Pregnancy
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HD 16102-03/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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