| A reversible preparation for observing the behavior of fetal rats in utero: spinal anesthesia with lidocaine. | |
| | |
MedLine Citation:
|
PMID: 3737724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A technique is described whereby lidocaine with epinephrine is injected into the spinal cord of the pregnant rat to produce reversible spinal anesthesia. This technique is useful for preparing pregnant females to study the spontaneous behavior of their fetuses in utero. Comparison of this procedure with an alternative, but irreversible, spinal preparation (chemomyelotomy) indicates that reversible lidocaine anesthesia does not differentially influence the activity of rat fetuses on Day 19 of gestation. This procedure will enable repeated observation of the same fetus at various stages of gestation and provide a means for the longitudinal study of behavioral development across the transition from prenatal to postnatal life. |
| | |
Authors:
|
W P Smotherman; S R Robinson; B J Miller |
Related Documents
:
|
18367344 - Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glyc... 2267604 - A histopathologic study of spinal cord ischemia using an isohistogenic rat upper-half-b... 17581924 - Role of gap junctions in spontaneous activity of the rat bladder. 8129984 - The occurrence of rat spinal cord neurons with strongly negative-charged surface coats. 9758204 - Effects of inhibitors of nitric oxide synthase on isolated uteri of fasting rats. 7523584 - Clorgyline effect on pineal melatonin biosynthesis in roman high- and low-avoidance rats. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Physiology & behavior Volume: 37 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1986 |
Date Detail:
|
Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 57-60 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, Spinal* Animals Behavior, Animal* / drug effects Embryonic and Fetal Development* / drug effects Female Fetal Movement / drug effects Gestational Age Lidocaine* Models, Biological Pregnancy Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
|
HD 16102-03/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of fluprazine hydrochloride on conspecific odor preferences in rats.
Next Document: Aversive-CS-specific alterations of evoked potentials in limbic and related areas of rats.