Document Detail


A reversible enteropathy complicating continuous hepatic artery infusion chemotherapy with 5-fluoro-2-deoxyuridine.
MedLine Citation:
PMID:  2931170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article describes two patients with hepatic metastases from colorectal cancer in whom a reversible enteropathy developed during the administration of hepatic artery infusion chemotherapy with 5-fluoro-2-deoxyuridine (5-FUdR) via an Infusaid Series 400 pump (Infusaid Corp., Sharon, MA). Both patients had severe diarrhea and signs that suggested small bowel obstruction. Barium studies revealed a distinctive radiologic appearance of severe narrowing of the ileum associated with complete loss of normal mucosal patterns. Results of an extensive evaluation for an infectious or toxin-related enterocolitis were negative. Perfusion studies confirmed the appropriate position of the catheters and revealed no extrahepatic perfusion. Systemic shunting of the 5-FUdR through the liver or tumor bed is postulated as the primary event, with the small bowel manifesting the major toxicity.
Authors:
W L Gluck; O E Akwari; F M Kelvin; B J Goodwin
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  56     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2424-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Floxuridine / administration & dosage,  adverse effects*
Hepatic Artery
Humans
Ileum / drug effects,  radiography
Infusions, Intra-Arterial / instrumentation
Intestinal Diseases / chemically induced*,  radiography
Intestinal Mucosa / drug effects,  radiography
Laparotomy
Liver Neoplasms / drug therapy,  secondary*
Male
Middle Aged
Chemical
Reg. No./Substance:
50-91-9/Floxuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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