Document Detail


The reversibility of impaired mucociliary function after lung transplantation.
MedLine Citation:
PMID:  1960996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impairment of mucociliary function occurs after lung transplantation and may predispose patients to repeated pulmonary infections. The purpose of this study is to determine whether and how soon such mucociliary function may recover. Ten dogs underwent left lung autotransplantation. Within 3 weeks five of these dogs underwent study for proximal airway clearance by observation through a bronchoscope of the movement of carbon particles placed at different locations on the tracheobronchial mucosa. The mechanical properties of collected mucus from specific sites were determined by magnetic rheometry. The right lung, which was not operated on, served as a paired control. Similar studies were conducted in the remaining five dogs at 12 weeks after autotransplantation. Lung autotransplantation caused significant depression of proximal airway clearance and a 35% increase in mucous rigidity (p = 0.05) soon after operation. At 12 weeks after operation, there was a partial recovery of proximal airway clearance. Mucous changes were no longer consistent. Histologic and electron microscopic examinations initially revealed focal denudation of ciliated cells and loss of the bronchial glands. At 12 weeks there was a regeneration of cilia and a reappearance of the bronchial glands. We conclude that the mucociliary function, observed to be depressed early after lung autotransplantation, recovers partially during the late postoperative period. Thus the mucociliary functional recovery should be attributed to revascularization rather than to reinnervation, since the latter is unlikely to occur during this period.
Authors:
D Marelli; A Paul; D M Nguyen; H Shennib; M King; N S Wang; J A Wilson; D S Mulder; R C Chiu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  102     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-09     Completed Date:  1992-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  908-12     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical
Animals
Ciliary Motility Disorders / physiopathology*
Dogs
Lung Transplantation / adverse effects*
Mucociliary Clearance*
Time Factors
Wound Healing

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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