Document Detail


The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast.
MedLine Citation:
PMID:  16518063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Invasive micropapillary carcinoma (IMPC) of the breast is a special subtype of invasive ductal carcinoma (IDC), which is known to have a high potential to metastasize to the axillary lymph node. However, it is sometimes difficult to differentiate IMPC from conventional IDC showing an IMPC-like pattern due to artifact (pseudo-IMPC). In the present study, we investigated the usefulness of immunohistochemical expression of MUC1 for distinguishing IMPC from pseudo-IMPC, and analyzed several clinicopathological parameters of IMPC and pseudo-IMPC cases. METHODS: Eighty cases showing IMPC or IMPC-like pattern were selected from our surgical files of 1,240 cases of IDC. We examined the expression of MUC1, D2-40 and CD34 by immunohistochemistry. RESULTS: Eighty cases were classified into 9 cases (0.7%) of pure-IMPC, 31 cases (2.5%) of mixed-IMPC, and 40 cases of pseudo-IMPC, according to the expression pattern of MUC1. In pure-IMPC cases, MUC1 expression was found at the reversed apical membrane of neoplastic cell clusters, while in pseudo-IMPC, MUC1 expression was present in the whole cytoplasmic membrane and/or cytoplasm. There were no significant differences among the three groups in patient age, tumor size and nuclear grade of neoplastic cells. However, lymphatic invasion and lymph node metastasis in the pure-IMPC or mixed-IMPC cases were higher than those in pseudo-IMPC cases with statistically significant values. Pure-IMPC has a higher recurrence rate and lower overall survival compared to pseudo-IMPC [P = 0.0165(DFS) P = 0.025(OS)]. CONCLUSIONS: This study demonstrated that immunohistochemistry of MUC1 is useful for the diagnosis of IMPC. The pure-IMPC cases had higher incidences of lymphatic invasion and lymph node metastasis, and also showed a poorer prognosis.
Authors:
Yu-sang Li; Mayumi Kaneko; Danielle Giacometti Sakamoto; Yukio Takeshima; Kouki Inai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Breast cancer (Tokyo, Japan)     Volume:  13     ISSN:  1340-6868     ISO Abbreviation:  Breast Cancer     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100888201     Medline TA:  Breast Cancer     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  IM    
Affiliation:
Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm
Breast Neoplasms / metabolism*,  pathology
Carcinoma, Ductal, Breast / metabolism*,  secondary
Carcinoma, Papillary / metabolism*,  secondary
Female
Humans
Immunoenzyme Techniques
Lymphatic Metastasis
Middle Aged
Mucin-1
Mucins / metabolism*
Neoplasm Invasiveness
Prognosis
Survival Rate
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/MUC1 protein, human; 0/Mucin-1; 0/Mucins

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