Document Detail

The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension.
MedLine Citation:
PMID:  6098957     Owner:  NLM     Status:  MEDLINE    
The precise mechanisms of hypertensive left ventricular hypertrophy and reversal with antihypertensive drugs are unclear and complex. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl), or a low (0.4% NaCl) salt diet. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), left ventricular weight/body weight (LVwt/Bwt) ratio were determined. Both drugs were effective in reducing blood pressure and left ventricular mass in DS rats placed on a high salt diet. For DR rats under the same conditions, only MK421 induced significant lowering of blood pressure. Neither drug caused significant change in ventricular mass. Both DS and DR rats on a low salt diet underwent significant blood pressure reduction with MK421 but not HTZ. Significant regression of the left ventricle was observed only in DS rats treated with MK421. Regression was not observed in DR rats even though MK421 reduced blood pressure to distinctly hypotensive levels. The dissociation of left ventricular mass and blood pressure control observed with both MK421 and HTZ suggests that pressure afterload is not the only factor involved in the pathophysiology of hypertensive cardiac hypertrophy. The mechanisms of anti-hypertensive drug action and salt intake both appear to play a significant if unexplained role.
P G Fernandez; W Snedden; H Idikio; D Fernandez; B K Kim; C R Triggle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  44     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-03-26     Completed Date:  1985-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  711-6     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Cardiomegaly / complications,  drug therapy*
Diet, Sodium-Restricted
Dipeptides / therapeutic use*
Heart Ventricles / drug effects
Hydrochlorothiazide / therapeutic use*
Hypertension / complications,  drug therapy*
Organ Size / drug effects
Rats, Inbred Strains
Reg. No./Substance:
0/Antihypertensive Agents; 0/Dipeptides; 58-93-5/Hydrochlorothiazide; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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