Document Detail

The reversal effect of low dose aminophylline on thiopental-induced sedation.
MedLine Citation:
PMID:  8252455     Owner:  NLM     Status:  MEDLINE    
Fifty-two ASA (American Society of Anesthesiologists) class I-II female patients, from 22 to 66 years of age, undergoing D & C (dilatation and curettage) procedure, were randomly divided into 2 groups in a double-blind and placebo-controlled design to investigate whether aminophylline could reverse the sedative effect of thiopental. Patients of both groups were anesthetized with fentanyl (2 micrograms/kg, i.v.) and thiopental (4 mg/kg, i.v. and 1 mg/kg, i.v. repeated if necessary). Postoperatively, they were intravenously given aminophylline (2 mg/kg) or normal saline in an equal volume solution over 5 minutes. The results showed that patients in the aminophylline group were more sedated (p < 0.05) than in the saline group 5 minutes after reversal, but were less sedated (p < 0.05) at minute 20. No significant differences between groups were found at other times. The total time spent in the postanesthetic unit was shorter in the aminophylline group (92 +/- 27 min.) than in the normal saline group (109 +/- 30 min.) (p < 0.05). The serum theophylline levels in some cases in the aminophylline group ranged between 3.2 and 4.9 micrograms/ml (4.3 +/- 0.7 micrograms/ml, n = 10). No apparent side effects, including tachyarrhythmias, were noted. We conclude that low dose aminophylline (2 mg/kg, i.v.) can partially reverse thiopental-induced sedation with safety in the early phase of recovery and it can reduce the total time spent in the postanesthetic unit.
Y C Chen; K H Chan; M Y Tsou; H Wang; Y Y Ho; T Y Lee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed     Volume:  52     ISSN:  0578-1337     ISO Abbreviation:  Zhonghua Yi Xue Za Zhi (Taipei)     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-10     Completed Date:  1994-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0005327     Medline TA:  Zhonghua Yi Xue Za Zhi (Taipei)     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
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MeSH Terms
Aminophylline / pharmacology*
Conscious Sedation / methods*
Double-Blind Method
Middle Aged
Receptors, GABA / drug effects
Thiopental / antagonists & inhibitors*,  blood
Time Factors
Reg. No./Substance:
0/Receptors, GABA; 317-34-0/Aminophylline; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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