| A retrospective study examining thrombolysis for occluded femoro-popliteal grafts - Is it worthwhile? | |
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MedLine Citation:
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PMID: 21875696 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To assess the effectiveness of catheter directed thrombolysis (CDT) in the treatment of acute graft occlusion. METHODS: Tissue prothrombin activator (rt-PA) was the sole agent used for thrombolysis. This was infused through a 4F straight 65 cm catheter placed under ultrasound guidance. Following a pre-CDT angiogram, a catheter was placed just proximal to the distal anastomosis. An infusion of rt-PA was given over 24 h. An assessment of acute clinical success, limb salvage rates, patency rates and complication rates were made over a period of one year. RESULTS: 80% (20/25) of grafts were successfully reopened immediately. 4/5 (80%) of the unsuccessful CDT cases required amputation within a few weeks. 60% (12/20) of successful CDT cases had an underlying stenotic lesion which required angioplasty. Limb salvage rate was 72% (18/25) at 12 months. There was no CDT related mortality. Secondary patency rate at 9 months was 76% (13/17). CONCLUSION: CDT can achieve reasonable results in this group of challenging patients and may be seen as a useful accessory in the vascular toolkit. However, precise indications for its use need further clarification. |
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Authors:
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C U Abraham-Igwe; M R S Siddiqui; L T Geddes; J Halls; A Irvine; N Browning |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-23 |
Journal Detail:
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Title: International journal of surgery (London, England) Volume: - ISSN: 1743-9159 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101228232 Medline TA: Int J Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Surgery, St Helier Hospital, Surrey, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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