| A retrospective study of bronchial hyperresponsiveness in patients with asthma before the onset of Churg-Strauss syndrome. | |
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MedLine Citation:
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PMID: 17619564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asthma is one of the most common clinical symptoms in Churg-Strauss syndrome (CSS). However, it is not known how lung function and bronchial hyperresponsiveness (BHR) prior to the development of CSS differs from asthmatics do not develop CSS. This retrospective cohort study was conducted to predict the onset of CSS and facilitate diagnosis in the early phase of the disease. We examined 24 pre-CSS asthmatic patients and 294 non-CSS asthmatic patients for clinical features, percent forced expiratory volume at 1 second (%FEV1), BHR to acetylcholine, and evaluated eosinophils (%) in the peripheral blood at their first hospital visit for asthma treatment. All of the 24 pre-CSS patients had adult-onset asthma. The asthma of 87.5% of pre-CSS patients at the first hospital visit before the onset of CSS was severe and was complicated by sinusitis. The eosinophils (%) in the peripheral blood was significantly higher than in non-CSS asthmatic patients. The %FEV1 in both the patients with severe asthma and the patients who developed CSS was lower than in patients with mild or moderate asthma. However, BHR in pre-CSS patients was significantly better than in non-CSS patients with severe asthma and was as mild as in patients with mild asthma. Patients who developed CSS had clinically severe asthma before the onset of CSS. The severity of their asthma was related to airflow limitation and eosinophilic inflammation in the peripheral blood, but not to BHR. These findings should prove useful in future early diagnosis and treatment of CSS. |
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Authors:
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Naomi Tsurikisawa; Takahiro Tsuburai; Hiroshi Saito; Sonoko Morita; Yoriko Horiguchi; Hiroyuki Mitomi; Kazuo Akiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergy and asthma proceedings : the official journal of regional and state allergy societies Volume: 28 ISSN: 1088-5412 ISO Abbreviation: Allergy Asthma Proc Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9603640 Medline TA: Allergy Asthma Proc Country: United States |
Other Details:
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Languages: eng Pagination: 336-43 Citation Subset: IM |
Affiliation:
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Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, Japan. n-tsurikisawa@sagamihara-hosp.gr.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Asthma / blood, immunology, physiopathology* Bronchial Hyperreactivity / blood, physiopathology* Churg-Strauss Syndrome / blood, physiopathology* Cohort Studies Enzyme-Linked Immunosorbent Assay Eosinophils / physiology Female Forced Expiratory Volume Humans Immunoglobulin E / blood, immunology* Intradermal Tests Male Middle Aged Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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