| A retrospective review of yttrium-90 synovectomy in the treatment of knee arthritis. | |
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MedLine Citation:
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PMID: 9374928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reviewed the case notes and X-rays of all patients with knee arthritis treated with yttrium-90 for the first time at a single institution from November 1981 to November 1995. Outcomes were assessed as 'improved' or 'not improved' by review of the case notes at 3, 6 and 12 months, and by the absence of further intra-articular (IA) steroid injections. Of the 121 knees treated, 87 had adequate follow-up information to allow an assessment of outcomes. Overall, 46% (95% CI 36-57) were improved at 12 months and 37% (95% CI 27-47) had no further IA injections (mean follow-up of 3.5 yr). Knees with osteoarthritis (OA) fared significantly worse with 10% (95% CI 0-29) vs 51% (95% CI 39-63) improved at 12 months (P < 0.05). Knees younger than 30 appeared to do better with 78% (95% CI 51-100) vs 28% (95% CI 17-45) having no further IA injections (P < 0.02). Knees with normal X-rays (Kellgren grade 0-1) did significantly better than those with more severe radiographic abnormalities (Kellgren grade 3-4), with 56% (95% CI 40-73) vs 24% (95% CI 8-40) improved (P < 0.01). Radiosynovectomy with yttrium-90 for knee arthritis appears to be of less value for patients with OA or with secondary OA changes on X-ray, and may be of more value for younger patients and those with spondyloarthropathies. |
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Authors:
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W J Taylor; M M Corkill; C N Rajapaske |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of rheumatology Volume: 36 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-12-15 Completed Date: 1997-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1100-5 Citation Subset: AIM; IM |
Affiliation:
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Wellington Regional Rheumatology Unit, Hutt Hospital, Hutt Valley Health Corporation Ltd, Lower Hutt, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arthritis / drug therapy, physiopathology, surgery* Combined Modality Therapy Female Humans Injections, Intra-Articular / methods Knee Joint / drug effects, radiography, surgery* Male Middle Aged Osteoarthritis / drug therapy, physiopathology, surgery Retrospective Studies Steroids / administration & dosage, therapeutic use Synovial Membrane / surgery* Time Factors Treatment Outcome Yttrium Radioisotopes |
| Chemical | |
Reg. No./Substance:
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0/Steroids; 0/Yttrium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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