Document Detail

A retrospective review of yttrium-90 synovectomy in the treatment of knee arthritis.
MedLine Citation:
PMID:  9374928     Owner:  NLM     Status:  MEDLINE    
We reviewed the case notes and X-rays of all patients with knee arthritis treated with yttrium-90 for the first time at a single institution from November 1981 to November 1995. Outcomes were assessed as 'improved' or 'not improved' by review of the case notes at 3, 6 and 12 months, and by the absence of further intra-articular (IA) steroid injections. Of the 121 knees treated, 87 had adequate follow-up information to allow an assessment of outcomes. Overall, 46% (95% CI 36-57) were improved at 12 months and 37% (95% CI 27-47) had no further IA injections (mean follow-up of 3.5 yr). Knees with osteoarthritis (OA) fared significantly worse with 10% (95% CI 0-29) vs 51% (95% CI 39-63) improved at 12 months (P < 0.05). Knees younger than 30 appeared to do better with 78% (95% CI 51-100) vs 28% (95% CI 17-45) having no further IA injections (P < 0.02). Knees with normal X-rays (Kellgren grade 0-1) did significantly better than those with more severe radiographic abnormalities (Kellgren grade 3-4), with 56% (95% CI 40-73) vs 24% (95% CI 8-40) improved (P < 0.01). Radiosynovectomy with yttrium-90 for knee arthritis appears to be of less value for patients with OA or with secondary OA changes on X-ray, and may be of more value for younger patients and those with spondyloarthropathies.
W J Taylor; M M Corkill; C N Rajapaske
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  36     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-15     Completed Date:  1997-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1100-5     Citation Subset:  AIM; IM    
Wellington Regional Rheumatology Unit, Hutt Hospital, Hutt Valley Health Corporation Ltd, Lower Hutt, New Zealand.
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MeSH Terms
Aged, 80 and over
Arthritis / drug therapy,  physiopathology,  surgery*
Combined Modality Therapy
Injections, Intra-Articular / methods
Knee Joint / drug effects,  radiography,  surgery*
Middle Aged
Osteoarthritis / drug therapy,  physiopathology,  surgery
Retrospective Studies
Steroids / administration & dosage,  therapeutic use
Synovial Membrane / surgery*
Time Factors
Treatment Outcome
Yttrium Radioisotopes
Reg. No./Substance:
0/Steroids; 0/Yttrium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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