Document Detail

A retrospective review of isoimmunized pregnancies managed by middle cerebral artery peak systolic velocity.
MedLine Citation:
PMID:  15284784     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the clinical outcome of isoimmunized pregnancies managed primarily by middle cerebral artery peak systolic velocity. STUDY DESIGN: A retrospective chart review was conducted of isoimmunized pregnancies that underwent ultrasound examinations from January 1, 2001, through May 1, 2003. Ultrasound reports, laboratory tests, and maternal and neonatal charts were reviewed. RESULTS: Women with a clinically significant red blood cell antibody and titer value were included. The study population consisted of 39 women (40 pregnancies, 42 fetuses). Patients with a middle cerebral artery peak systolic velocity of > or =1.5 MoM were offered amniocentesis. Seven pregnancies had an abnormal middle cerebral artery peak systolic velocity. Three of these infants had significant anemia. Six of the 7 pregnancies required an exchange transfusion. None of the 33 pregnancies (35 neonates) with normal middle cerebral artery peak systolic velocity measurements resulted in a neonate with significant anemia or severe hyperbilirubinemia. CONCLUSION: The clinical outcome of these pregnancies supports the use of middle cerebral artery peak systolic velocity measurements in the management of isoimmunized pregnancies.
Lynn K McLean; Herman L Hedriana; Jan M Lanouette; Hanns C Haesslein
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  190     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1732-6; discussion 1736-8     Citation Subset:  AIM; IM    
Sacramento Maternal-Fetal Medicine Medical Group, Sutter Medical Center, CA, USA.
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MeSH Terms
Blood Flow Velocity
Cohort Studies
Follow-Up Studies
Gestational Age
Middle Cerebral Artery*
Pregnancy Complications, Hematologic / diagnosis*,  therapy
Retrospective Studies
Rh Isoimmunization / diagnosis*,  physiopathology,  therapy
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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