| A retrospective review of the effect of COX-2 inhibitors on blood pressure change. | |
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MedLine Citation:
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PMID: 12975714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to compare the difference between celecoxib and rofecoxib on blood pressure change. A retrospective review of medical records where the mean blood pressure in a 90-day period before and after start of the cyclooxygenase (COX)-2 inhibitors, celecoxib, and rofecoxib was compared. Data were abstracted from 249 patient records, of which 109 were included. The mean systolic blood pressures at baseline were comparable at 134.14 mm Hg and 134.05 mm Hg for the celecoxib (n = 52) and rofecoxib groups (n = 57), respectively (P = NS). A nonsignificant decrease in systolic blood pressure was observed for the celecoxib group (-1.15 mm Hg), while a statistically significant increase in systolic blood pressure was seen in the rofecoxib group (4.76 mm Hg, P = 0.044). The mean diastolic blood pressures at baseline were not significantly different between the two groups, and changes in the postperiod were also not statistically different compared with baseline values. The average total daily dose of COX-2 inhibitor was 219.2 mg for celecoxib and 25.23 mg for rofecoxib. A post hoc analysis of patients aged 65 years and older showed that the mean systolic blood pressure in the rofecoxib group increased by 7.37 mm Hg (P = 0.016), while there was an insignificant decrease for the celecoxib group (-1.94 mm Hg). This study showed that there were no significant changes in blood pressure after celecoxib initiation. While in the rofecoxib group, there was a significant increase in systolic blood pressure with an even greater increase for patients aged 65 years and older. |
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Authors:
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Jeannie Cho; Catherine E Cooke; Woody Proveaux |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of therapeutics Volume: 10 ISSN: 1075-2765 ISO Abbreviation: Am J Ther Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2003-09-16 Completed Date: 2004-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: IM |
Affiliation:
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Global Health Outcomes, Pharmacia Corporation, Peapack, NJ, USA. mjeanniecho@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Antihypertensive Agents / administration & dosage, pharmacology* Blood Pressure / drug effects* Cardiovascular System / drug effects Cyclooxygenase Inhibitors / administration & dosage, pharmacology* Female Humans Hypertension / drug therapy* Lactones / administration & dosage, pharmacology* Male Medical Records Middle Aged Pyrazoles Retrospective Studies Risk Factors Sulfonamides / administration & dosage, pharmacology* Sulfones Time Factors United States |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Cyclooxygenase Inhibitors; 0/Lactones; 0/Pyrazoles; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 169590-42-5/celecoxib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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