Document Detail


A retrospective monocenter review of simultaneous pancreas-kidney transplantation.
MedLine Citation:
PMID:  19857755     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: Herein we have reviewed a consecutive series of simultaneous pancreas-kidney (SPK) transplantations performed at our institution over a 6-year period. PATIENTS AND METHODS: The study population included 22 patients (15 males and 7 females) who underwent SPK transplantation between 2001 and 2007. The mean recipient age was 47 years (range, 26-63 years). Eighteen patients suffered type 1 and 4 type 2 diabetes mellitus. The mean donor age was 33 years (range, 14-56 years). The mean HLA match was 2.1 (range, 1-5). Immunosuppressive treatment consisted of basiliximab induction followed by tacrolimus, mycophenolate mofetil, and prednisone. RESULTS: The mean hospital stay was 20 days (range, 11-52 days). After a mean follow-up of 44 months (range, 17-88 months), patient, kidney, and pancreas graft survivals were 86%, 82%, and 73%, respectively. Two patients died in the immediate postoperative period due to, respectively, disseminated intravascular coagulation and pulmonary embolism. A kidney graft was lost due to early hyperacute rejection. Other early complications associated with the pancreas graft included 2 cases of immediate reperfusion defects that led to early vascular thrombosis in 1 patient and a duodenal graft fistula in the other patient; a third patient developed type 2 diabetes mellitus. Beyond the postoperative period, graft loss was limited to 1 case of noncompliance to the immunosuppressive medications and 1 death secondary to pulmonary infection with a functional allograft after 4 years. CONCLUSIONS: SPK transplantation is a valid therapeutic option for patients with insulin-dependent diabetes mellitus and renal failure due to diabetic nephropathy. The main complications of SPK transplantation occur in the immediate postoperative period consequent to vascular or rejection processes.
Authors:
E Decker; C Coimbra; L Weekers; O Detry; P Honoré; J-P Squifflet; M Meurisse; A De Roover
Related Documents :
1440855 - The effects of steroid withdrawal on the lipoprotein profiles of cyclosporine-treated k...
15604575 - Alternative grafting technique for patients unsuited to heterotopic transplantation due...
21440765 - Factors associated with insulin resistance after long-term renal transplantation.
21326735 - A case of pancreatic islet cell transplantation in a patient with situs ambiguous: anat...
22198495 - Preservation of pancreas graft function after complete venous thrombosis: report of fou...
18220895 - Hematopoietic stem cell transplantation from alternative donors for high-risk acute leu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  41     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3389-92     Citation Subset:  IM    
Affiliation:
Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, B4000 Liège, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Discriminate liver warm ischemic injury during hypothermic machine perfusion by proton magnetic reso...
Next Document:  Balancing efficacy and toxicity of kidney transplant immunosuppression.