Document Detail

A retrospective look at horses exhibiting unusual clinical signs after exercising on L-NAME.
MedLine Citation:
PMID:  10509444     Owner:  NLM     Status:  MEDLINE    
Three of 5 horses exercising on L-NAME (NG-nitro-L-arginine methyl ester) exhibited unusual clinical signs towards the end of exercise bouts and post-exercise. L-NAME is a nitric oxide synthase inhibitor which blocks synthesis of nitric oxide from L-arginine. The induced absence of nitric oxide may have lead to the clinical signs observed.
L L Gallatin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  41     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-26     Completed Date:  1999-11-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-41     Citation Subset:  IM    
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
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MeSH Terms
Horses / physiology*
NG-Nitroarginine Methyl Ester / adverse effects*
Nitric Oxide / physiology*
Physical Conditioning, Animal / adverse effects*
Retrospective Studies
Reg. No./Substance:
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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