Document Detail


A retrospective comparison of two drug regimens RHE2/RH10 and RHZ2/RH10 in the treatment of tuberculous mediastinal lymphadenopathy.
MedLine Citation:
PMID:  3248208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective radiographic comparison of two regimens, RHE2/RH10 (n = 32) and RHZ2/RH10 (n = 37), used in the treatment of tuberculous mediastinal lymphadenopathy is reported. The two groups did not differ in age, pretreatment or post-treatment values. The rate of improvement in serial radiographs was compared between the two groups, each patient acting as his own control. There was no difference in the incidence of initial gland enlargement at 1 month, but at 2 months RHZ2/RH10 had less enlargement (0.05 greater than P greater than 0.01). The rate of improvement was faster in the RHZ2/RH10 group from 2-7 months' treatment, being significantly better than RHE2/RH10 at 2 (P = 0.003), 5 (0.01 greater than P) and 7 months (0.02 greater than P). Pyrazinamide (25-40 mg/kg) appears to be superior to ethambutol 15 mg/kg for the initial 2 months of treatment of tuberculous mediastinal lymphadenopathy. The findings may be applicable to peripheral tuberculous lymphadenopathy.
Authors:
L P Ormerod
Related Documents :
14592288 - Management of restless legs syndrome by the partial d2-agonist terguride.
25362748 - Pain management after total knee arthroplasty: a case–control study of continuous ner...
22081178 - Comparative study between combination of famciclovir and prednisolone with prednisolone...
11339478 - Concentration of soluble cd4, cd8 and cd25 receptors in early localized and early disse...
20694038 - Assessment of relapse following intraoral vertical ramus osteotomy mandibular setback a...
20134308 - Outcomes of a standardized surgical and rehabilitation program in transtibial amputatio...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of diseases of the chest     Volume:  82     ISSN:  0007-0971     ISO Abbreviation:  Br J Dis Chest     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-07-07     Completed Date:  1989-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511123     Medline TA:  Br J Dis Chest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Affiliation:
Chest Clinic, Blackburn Royal Infirmary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Drug Therapy, Combination
Ethambutol / therapeutic use*
Female
Humans
Isoniazid / therapeutic use*
Male
Mediastinal Diseases / drug therapy*,  radiography
Middle Aged
Pyrazinamide / therapeutic use*
Rifampin / therapeutic use*
Time Factors
Tuberculosis, Lymph Node / drug therapy*,  radiography
Chemical
Reg. No./Substance:
13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 98-96-4/Pyrazinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunohistochemical localization of native and denatured collagen types I and II in fetal and adult ...
Next Document:  Profiles of non-compliance with antituberculous therapy.