Document Detail

A retrospective comparison of two drug regimens RHE2/RH10 and RHZ2/RH10 in the treatment of tuberculous mediastinal lymphadenopathy.
MedLine Citation:
PMID:  3248208     Owner:  NLM     Status:  MEDLINE    
A retrospective radiographic comparison of two regimens, RHE2/RH10 (n = 32) and RHZ2/RH10 (n = 37), used in the treatment of tuberculous mediastinal lymphadenopathy is reported. The two groups did not differ in age, pretreatment or post-treatment values. The rate of improvement in serial radiographs was compared between the two groups, each patient acting as his own control. There was no difference in the incidence of initial gland enlargement at 1 month, but at 2 months RHZ2/RH10 had less enlargement (0.05 greater than P greater than 0.01). The rate of improvement was faster in the RHZ2/RH10 group from 2-7 months' treatment, being significantly better than RHE2/RH10 at 2 (P = 0.003), 5 (0.01 greater than P) and 7 months (0.02 greater than P). Pyrazinamide (25-40 mg/kg) appears to be superior to ethambutol 15 mg/kg for the initial 2 months of treatment of tuberculous mediastinal lymphadenopathy. The findings may be applicable to peripheral tuberculous lymphadenopathy.
L P Ormerod
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of diseases of the chest     Volume:  82     ISSN:  0007-0971     ISO Abbreviation:  Br J Dis Chest     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-07-07     Completed Date:  1989-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511123     Medline TA:  Br J Dis Chest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Chest Clinic, Blackburn Royal Infirmary.
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MeSH Terms
Drug Therapy, Combination
Ethambutol / therapeutic use*
Isoniazid / therapeutic use*
Mediastinal Diseases / drug therapy*,  radiography
Middle Aged
Pyrazinamide / therapeutic use*
Rifampin / therapeutic use*
Time Factors
Tuberculosis, Lymph Node / drug therapy*,  radiography
Reg. No./Substance:
13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 98-96-4/Pyrazinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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