| A retrospective comparison of two drug regimens RHE2/RH10 and RHZ2/RH10 in the treatment of tuberculous mediastinal lymphadenopathy. | |
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MedLine Citation:
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PMID: 3248208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective radiographic comparison of two regimens, RHE2/RH10 (n = 32) and RHZ2/RH10 (n = 37), used in the treatment of tuberculous mediastinal lymphadenopathy is reported. The two groups did not differ in age, pretreatment or post-treatment values. The rate of improvement in serial radiographs was compared between the two groups, each patient acting as his own control. There was no difference in the incidence of initial gland enlargement at 1 month, but at 2 months RHZ2/RH10 had less enlargement (0.05 greater than P greater than 0.01). The rate of improvement was faster in the RHZ2/RH10 group from 2-7 months' treatment, being significantly better than RHE2/RH10 at 2 (P = 0.003), 5 (0.01 greater than P) and 7 months (0.02 greater than P). Pyrazinamide (25-40 mg/kg) appears to be superior to ethambutol 15 mg/kg for the initial 2 months of treatment of tuberculous mediastinal lymphadenopathy. The findings may be applicable to peripheral tuberculous lymphadenopathy. |
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Authors:
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L P Ormerod |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of diseases of the chest Volume: 82 ISSN: 0007-0971 ISO Abbreviation: Br J Dis Chest Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1989-07-07 Completed Date: 1989-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7511123 Medline TA: Br J Dis Chest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 274-81 Citation Subset: IM |
Affiliation:
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Chest Clinic, Blackburn Royal Infirmary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Drug Therapy, Combination Ethambutol / therapeutic use* Female Humans Isoniazid / therapeutic use* Male Mediastinal Diseases / drug therapy*, radiography Middle Aged Pyrazinamide / therapeutic use* Rifampin / therapeutic use* Time Factors Tuberculosis, Lymph Node / drug therapy*, radiography |
| Chemical | |
Reg. No./Substance:
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13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 98-96-4/Pyrazinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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